vindesine

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Names

[ Name ]:
vindesine

[Synonym ]:
2H-3,7-Methanoazacycloundecino[5,4-b]indole-9-carboxylic acid, 9-[(2β,3β,4β,5α,12β,19α)-3-(aminocarbonyl)-6,7-didehydro-3,4-dihydroxy-16-methoxy-1-methylaspidospermidin-15-yl]-5-et hyl-1,4,5,6,7,8,9,14b-octahydro-5-hydroxy-, methyl ester, (5S,7S,9S)-
Vindesin
EINECS 258-682-2
methyl (5S,7S,9S)-9-[(2β,3β,4β,5α,12β,19α)-3-(aminocarbonyl)-3,4-dihydroxy-1-methyl-16-(methyloxy)-6,7-didehydroaspidospermidin-15-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,14b-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate
Vindesinum
4-Desacetylleurosidin-C-3-carboxamid
Vindesina
Methyl (13S,15S,17S)-13-[(2β,3β,4β,5α,12β,19α)-3-carbamoyl-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidin-15-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.0.0]nonadeca-5,7,9,11-tetraene-13-carboxylate
Desacetylvinblastine amide
Eldesine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
230-232ºC

[ Molecular Formula ]:
C₄₃H₅₅N₅O₇

[ Molecular Weight ]:
753.926

[ Exact Mass ]:
753.410156

[ PSA ]:
164.82000

[ LogP ]:
2.94

[ Index of Refraction ]:
1.708

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YY8080000

CHEMICAL NAME :: Vincaleukoblastine, 3-(aminocarbonyl)-O(sup 4)-deacetyl-3-de(methoxycarbonyl)-

CAS REGISTRY NUMBER :: 53643-48-4

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C43-H55-N5-O7

MOLECULAR WEIGHT :: 754.03

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13800 ug/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TEST SYSTEM :: Rodent - hamster

DOSE/DURATION :: 1100 ug/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 174,11,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7287 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated) No. of Female Employees: 14 (estimated)

Safety Information

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Related Compounds

Vindesine sulfate
bis(N-ethylidene vindesine)disulfide
{1-Methyl-5-oxaspiro[2.4]heptan-6-yl}methanol
3-Chloro-2-methylphenyl chloroformate
2-Fluoro-5-prop-1-en-2-ylaniline
2-(2-Amino-5-(4-methoxyphenyl)-6-(trifluoromethyl)pyrimidin-4-yl)-5-((2-methylallyl)oxy)phenol
2-(2-Amino-5-(3,4-dimethoxyphenyl)pyrimidin-4-yl)-5-((2-methylbenzyl)oxy)phenol
2-(2-Amino-5-(3-methoxyphenoxy)pyrimidin-4-yl)-5-((2,5-dimethylbenzyl)oxy)phenol
Ethyl(imino)(3-methylbutyl)-lambda6-sulfanone
Tert-butyl 3-fluoro-3-(2-methylpropanoyl)azetidine-1-carboxylate
4-Chloro-2-methyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine
Cyclopentyl(imino)(2-methylpropyl)-lambda6-sulfanone

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