5-Chloro-2-nitrotoluene

Names

[ CAS No. ]:
5367-28-2

[ Name ]:
5-Chloro-2-nitrotoluene

[Synonym ]:
Benzene, 4-chloro-2-methyl-1-nitro-
4-Chloro-2-methyl-1-nitrobenzene
MFCD00024579
EINECS 226-355-3

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
249.0±20.0 °C at 760 mmHg

[ Melting Point ]:
27-30 °C(lit.)

[ Molecular Formula ]:
C₇H₆ClNO₂

[ Molecular Weight ]:
171.581

[ Flash Point ]:
104.4±21.8 °C

[ Exact Mass ]:
171.008713

[ PSA ]:
45.82000

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.570

[ Water Solubility ]:
insoluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS9134000

CHEMICAL NAME :: Toluene, 5-chloro-2-nitro-

CAS REGISTRY NUMBER :: 5367-28-2

BEILSTEIN REFERENCE NO. :: 2502585

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H6-Cl-N-O2

MOLECULAR WEIGHT :: 171.59

WISWESSER LINE NOTATION :: WNR DG B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 11,184,1974

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39-S61

[ RIDADR ]:
UN 3457 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
XS9134000

[ HS Code ]:
2904909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-Chlorotoluene
4-Chloronitrobenzene
2,4-Dinitrotoluene
m-toluenediazonium chloride
nitric acid
3-Methyl-4-nitroaniline

DownStream

5-Chloroindole
4-Chloro-2-Methylaniline
5-Chloro-2-phenyl-1H-indole
(2-Bromomethyl)-4-chloro-1-nitrobenzene
2-Amino-5-chlorobenzoic acid
2-METHYL-1-NITRO-4-(TRIFLUOROMETHYL)BENZENE
5-Chloro-2-nitrobenzoic acid
2-methyl-1-nitro-4-(2-nitrophenyl)sulfanylbenzene
diethyl 2-methyl-2-(3-methyl-4-nitrophenyl)propanedioate
2-methyl-1-nitro-4-phenylsulfanylbenzene

Customs

[ HS Code ]: 2904909090

[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Effects of chlorphenamidine and its metabolites on HeLa cells.

Bull. Environ. Contam. Toxicol. 11(2) , 184-8, (1974)

5-Chloro-2-methyl-3-nitroaniline
5-Chloro-2-methyl-4-nitroaniline
5-chloro-4-ethoxy-2-nitrotoluene
5-Chloro-2-fluorobenzaldehyde
5-chloro-2,4-difluoro-6-methylpyrimidine
5-Chloro-2-hydroxybenzophenone
4-(3-Chloroprop-1-en-2-yl)pyridine
1-Bromohexane-4,4,5,5,6,6,6-D7
Tert-butyl 3-amino-3-(thiophen-3-yl)piperidine-1-carboxylate
1-[3-Amino-3-(5-methoxypyridin-3-yl)piperidin-1-yl]-2,2,2-trifluoroethan-1-one
4-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetyl}morpholine-3-carboxylic acid
2-[({2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropyl}formamido)methyl]cyclopentane-1-carboxylic acid
tert-butyl N-[3-amino-2-(2-chloro-4-fluorophenyl)-2-methylpropyl]carbamate
3-{N-cyclopropyl-3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methylpentanamido}propanoic acid
(2R)-2-{[1-benzyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-4-yl]formamido}-4-hydroxybutanoic acid
(3S)-1-[1-benzyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)piperidine-4-carbonyl]piperidine-3-carboxylic acid

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