Guanicaine

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Names

[ CAS No. ]:
537-05-3

[ Name ]:
Guanicaine

[Synonym ]:
Guanicaine
Acoin
Diparaanisyl-monophenethyl-guanidin-hydrochlorid [German]
2-(4-Ethoxyphenyl)-1,3-bis(4-methoxyphenyl)guanidine hydrochloride
Dianisyl-monophenethylguanidine hydrochloride
Akoin hydrochlorid [German]
Phenodianisyl
Phenodianisyl hydrochloride
Acoine
Acoin hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
545.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₂₆ClN₃O₃

[ Molecular Weight ]:
427.92400

[ Flash Point ]:
284ºC

[ Exact Mass ]:
427.16600

[ PSA ]:
64.11000

[ LogP ]:
6.26220

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF2000000

CHEMICAL NAME :: Guanidine, 2-(p-ethoxyphenyl)-1,3-bis(p-methoxyphenyl)-, hydrochloride

CAS REGISTRY NUMBER :: 537-05-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C23-H25-N3-O3.Cl-H

MOLECULAR WEIGHT :: 427.97

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

REFERENCE :: HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933 Volume(issue)/page/year: -,-,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,1043,1983

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935

Safety Information

[ HS Code ]:
2925290090

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds

7,8-Dichloro-3,4-dihydroquinazolin-4-one
4-Aminobenzo[4,5]imidazo[1,2-c]pyrimidin-1(5H)-one
Methyl 4-bromo-6-[(1,1-dimethylethyl)amino]-2-pyridinecarboxylate
N-(((2-((2-Chloroethyl)amino)ethyl)thio)methyl)acetamide
7-Fluoropyrrolo[2,1-f][1,2,4]triazin-4-amine
tert-butyl N-[1-(3-bromopyridin-2-yl)ethyl]carbamate
tert-Butyl5-fluoro-2,8-diazaspiro[5.5]undecane-2-carboxylate
Ethyl 2-(2-amino-3-methylphenyl)acetate
N-Boc-6-bromo-L-norleucine tert-butyl ester
N-Cyclopropyl-4-(4-iodo-1-methyl-1H-pyrazol-5-YL)pyrimidin-2-amine

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