Tubacin

Suppliers

Names

[ Name ]:
Tubacin

[Synonym ]:
UNII:02C2G1D30D
Octanediamide, N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N-hydroxy-
N-(4-{(2R,4R,6S)-4-{[(4,5-Diphenyl-1,3-oxazol-2-yl)sulfanyl]methyl}-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl}phenyl)-N'-hydroxyoctanediamide

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₄₁H₄₃N₃O₇S

[ Molecular Weight ]:
721.861

[ Exact Mass ]:
721.282166

[ PSA ]:
168.45000

[ LogP ]:
5.82

[ Appearance of Characters ]:
white to tan

[ Index of Refraction ]:
1.668

[ Storage condition ]:
?20°C

[ Water Solubility ]:
DMSO: ≥10mg/mL

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation.

Cell Death Dis. 5 , e1447, (2014)

Acetylation status of DNA end joining protein Ku70 dictates its function in DNA repair and Bax-mediated apoptosis. Despite the knowledge of HDACs and HATs that are reported to modulate the acetylation...

Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells.

Cancer Biol. Ther. 15(6) , 742-57, (2014)

Epigenetic modifiers such as histone deacetylases (HDACs) have come into focus as novel drug targets for cancer therapy due to their functional role in tumor progression. Since common pan-HDAC inhibit...

Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.

Cancer Res. 74(24) , 7475-86, (2014)

Histone deacetylases (HDAC) that regulate gene expression are being explored as cancer therapeutic targets. In this study, we focused on HDAC6 based on its ability to inhibit cancerous Hsp90 chaperone...

Tubacin
6-(Pyridin-3-yl-[1,2,4]oxadiazol-5-yl)pyridine-2-carbonitrile
4,4'-(4A,9a-dihydro-9H-fluorene-9,9-diyl)bis(2-methylphenol)
5-(3-Pyridin-3-yl-[1,2,4]oxadiazol-5-yl)furan-2-carbonitrile
5-(3-Pyridin-3-yl-[1,2,4]oxadiazol-5-yl)-thiophene-2-carbonitrile
Acetylechimidine
N-{2-[(Acetylamino)methyl]-1,3-benzothiazol-5-yl}-4-tert-butylbenzamide
N-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)furan-2-carboxamide
Benzamide,4-chloro-n-(4-chlorobenzoyl)-
Propyl 2-nitro-5-propoxybenzoate
Hydroxymifepristone, (6beta)-

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