Cytochalasin H
Suppliers
Names
[ CAS No. ]:
53760-19-3
[ Name ]:
Cytochalasin H
[Synonym ]:
<11>Cytochalasin
paspalin
19-triene-1-one
cytochalasin U
paspalinpi
Paspalin P1
cytochalasinhfromphomopsissp.
kodocytochalasin-1
Chemical & Physical Properties
[ Density]:
1.19g/cm3
[ Boiling Point ]:
676.5ºC at 760mmHg
[ Melting Point ]:
252-258ºC
[ Molecular Formula ]:
C30H39NO5
[ Molecular Weight ]:
493.63
[ Flash Point ]:
362.9ºC
[ Exact Mass ]:
493.28300
[ PSA ]:
95.86000
[ LogP ]:
4.06690
[ Index of Refraction ]:
1.591
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
chloroform: 10 mg/mL, clear, colorless
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HA5306000
- CHEMICAL NAME :
- (11)Cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10- phenyl-, (7S,13E,16S,18S,19E,21R)-
- CAS REGISTRY NUMBER :
- 53760-19-3
- LAST UPDATED :
- 199107
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C30-H39-N-O5
- MOLECULAR WEIGHT :
- 493.70
- WISWESSER LINE NOTATION :
- T56-11- 1A R AXVM GY JU PUTJ D1R& F1 GU1 HQ M1 OQ O1 ROV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 12500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 2341 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 500 ug/L
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,430,1978
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300-H310-H330-H361
[ Precautionary Statements ]:
P260-P264-P280-P284-P302 + P350-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+
[ Risk Phrases ]:
26/27/28-63
[ Safety Phrases ]:
28-36/37-45
[ RIDADR ]:
UN 3462 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
HA5306000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1(a)
Synthetic Route
Articles
Acta Microbiol. Acad. Sci. Hung. 22 , 253, (1975)
A new fungal isolate from the host plant Paspalum scrobiculatum Linn., is reported. It is characterized and designated as a separate species Phomopsis paspali (n. sp.), not only for the different morp...
Toxicology 33(3-4) , 323-30, (1984)
Effects of the mould metabolite, cytochalasin H (CH) were studied in chick embryos explanted at stages 4, 5 and 8 and cultured in vitro. Morphological and histological observations revealed that the m...
Exp. Cell Biol. 50(3) , 155-61, (1982)
Cytochalasin H (CH) has been shown to inhibit the reaggregation of dissociated cells of a fresh water sponge. The effect is dose-dependent and reversible. Even after 24 h of CH treatment, the cells sh...