2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide

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Names

[ CAS No. ]:
53859-37-3

[ Name ]:
2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide

[Synonym ]:
Dechlorcyclophosphamide
B 516
N,N-Diethylcyclophosphamide
Didechlorocyclophosphamide
ASTA 7019
n,n-diethyl-1,3,2-oxazaphosphinan-2-amine 2-oxide
ASTA B 516

Chemical & Physical Properties

[ Density]:
1.11g/cm3

[ Boiling Point ]:
249ºC at 760mmHg

[ Molecular Formula ]:
C7H17N2O2P

[ Molecular Weight ]:
192.19600

[ Flash Point ]:
104.4ºC

[ Exact Mass ]:
192.10300

[ PSA ]:
51.38000

[ LogP ]:
1.77500

[ Index of Refraction ]:
1.473

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP5788700
CHEMICAL NAME :
2H-1,3,2-Oxazaphosphorin-2-amine, tetrahydro-N,N-diethyl-, 2-oxide
CAS REGISTRY NUMBER :
53859-37-3
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C7-H17-N2-O2-P
MOLECULAR WEIGHT :
192.23
WISWESSER LINE NOTATION :
T6MPOTJ BO BN2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Bird - chicken Cells - not otherwise specified
DOSE/DURATION :
211 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,115,1992

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Diethylphosphoramidic dichloride
  • 3-Aminopropan-1-ol
  • Diethylamine

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1,1-Dimethylethyl 4-hydroxy-2-methylbenzeneacetate
  • Ethyl 18-bromooctadecanoate
  • 6-(2,6-Dichlorophenyl)-2-((4-(4-(dimethylamino)piperidin-1-yl)-3-methylphenyl)amino)imidazo[1,2-b]pyrimido[4,5-d]pyridazin-5(6H)-one
  • tert-butyl N-(2-amino-4,4-difluoropentyl)carbamate
  • rel-1,1-Dimethylethyl N-[(1R,2S)-2-(4-chlorophenyl)cyclopropyl]carbamate
  • ethyl N-[(2-phenylethyl)carbamothioyl]carbamate
  • 5-([1,1'-Biphenyl]-4-yl)-5,11-dihydroindolo[3,2-b]carbazole
  • (E)-6-(Naphthalen-2-yl)imidazo[2,1-b]oxazole-5-carbaldehyde O-3,4-dichlorobenzyl oxime
  • tert-butyl (R)-2-(cyclopentanecarbonyl)pyrrolidine-1-carboxylate
  • tert-butyl (S)-2-(cyclobutanecarbonyl)pyrrolidine-1-carboxylate
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