Furylacrylic acid

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Names

[ CAS No. ]:
539-47-9

[ Name ]:
Furylacrylic acid

[Synonym ]:
2-Propenoic acid, 3-(2-furanyl)-, (2E)-
Furfurylidene Acetic Acid
β-(2-Furyl)acrylic acid
2-Propenoic acid, 3- (2-furanyl)-
2-Propenoic acid, 3-(2-furanyl)-
EINECS 208-718-8
2-Furanacrylic Acid
b-2-Furylacrylic Acid
(2E)-3-(2-Furyl)acrylic acid
MFCD00003257
3-(Furan-2-yl)acrylic acid
3-(2-Furyl)acrylic Acid
Furylacrylic acid
Nalfurafine Impurity 7

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
286.0±0.0 °C at 760 mmHg

[ Melting Point ]:
139-141 °C(lit.)

[ Molecular Formula ]:
C₇H₆O₃

[ Molecular Weight ]:
138.121

[ Flash Point ]:
106.8±20.4 °C

[ Exact Mass ]:
138.031693

[ PSA ]:
50.44000

[ LogP ]:
2.03

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.582

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LT8560000

CHEMICAL NAME :: 2-Furanacrylic acid

CAS REGISTRY NUMBER :: 539-47-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H6-O3

MOLECULAR WEIGHT :: 138.13

WISWESSER LINE NOTATION :: T5OJ B1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 276 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,15,1978

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LT8560000

[ HS Code ]:
29321900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Furfural
Malonic acid
Ethanoic anhydride
Diethylphosphonoacetic acid
5-(furan-2-ylmethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione
Piperidine
trimethyl-(2-trimethylsilyl-1-trimethylsilyloxyethenoxy)silane
Diethyl malonate
2-Propenoic acid,3-(2-furanyl)-, ethyl ester
Furylacrolein

DownStream

3-(furan-2-yl)-N,N-dimethylprop-2-enamide
4-chlorofuro-[3,2-c]-pyridine
ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate
3-(furan-2-yl)prop-2-enoyl chloride
ethenyl 3-(furan-2-yl)prop-2-enoate
2-Propenamide,3-(2-furanyl)-N-(1-methylethyl)-
Furan-2-carboxylic acid
acetic acid
3-(Tetrahydro-furan-2-yl)propionic acid
5-Propyldihydro-2(3H)-furanone

Customs

[ HS Code ]: 29321900

Articles

Substrate specificity and kinetic characteristics of angiotensin converting enzyme.

Biochemistry 22(1) , 103-10, (1983)

Furanacryloyl-Phe-Gly-Gly has been shown to be a convenient substrate for angiotensin converting enzyme (dipeptidyl carboxypeptidase, EC 3.4.15.1). A detailed kinetic analysis of the hydrolysis of thi...

Activation of angiotensin converting enzyme by monovalent anions.

Biochemistry 22(1) , 110-6, (1983)

The angiotensin converting enzyme catalyzed hydrolysis of furanacryloyl-Phe-Gly-Gly is activated by monovalent anions in the order C1- greater than Br- greater than F- greater than NO3- greater than C...

Esters of 2-furanacrylic acid.

J. Am. Chem. Soc. 69(2) , 460, (1947)