1,2-Ethanediol,1-carbamate

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Names

[ CAS No. ]:
5395-01-7

[ Name ]:
1,2-Ethanediol,1-carbamate

[Synonym ]:
HYDROXYETHYL CARBAMATE
carbamic 2-hydroxyethylester
1,2-Ethanediol,monocarbamate
Ethylene glycol monocarbamate
Carbamidsaeure-(2-hydroxy-aethylester)
Carbamic acid,2-hydroxyethyl ester
ethylene glycol carbamate
methanol,methyl carbamate
2-Hydroxyethylcarbamate

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
321.5ºC at 760mmHg

[ Melting Point ]:
43ºC

[ Molecular Formula ]:
C3H7NO3

[ Molecular Weight ]:
105.09300

[ Flash Point ]:
148.2ºC

[ Exact Mass ]:
105.04300

[ PSA ]:
72.55000

[ Index of Refraction ]:
1.463

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FB1925000
CHEMICAL NAME :
Carbamic acid, 2-hydroxyethyl ester
CAS REGISTRY NUMBER :
5395-01-7
BEILSTEIN REFERENCE NO. :
1746943
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C3-H7-N-O3
MOLECULAR WEIGHT :
105.11
WISWESSER LINE NOTATION :
ZVO2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
505 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 gm/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,1437,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethylene carbonate
  • Ethylene glycol
  • Urea
  • Ammonia
  • Water

DownStream

  • oxazolidinone
  • 2-carbamoyloxyethyl carbamate
  • 2-Chloroethyl carbamate

Related Compounds

  • 1,2-Ethanediol,1-phenyl-, 2-carbamate
  • 1,2-Ethanediol,1-(4-fluorophenyl)-,(1R)-(9CI)
  • 1,2-Ethanediol,1-formate
  • 1,2-Ethanediol,1,2-dibenzenesulfonate
  • 1,2-Ethanediol,1,2-bis(1H-benzimidazol-2-yl)-
  • 1,2-Ethanediol,1-(4-pyridinyl)-,(1R)-(9CI)
  • 6-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4-oxo-N-(4-propoxybenzyl)-4H-chromene-2-carboxamide
  • N-(4-tert-butylbenzyl)-6-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4-oxo-4H-chromene-2-carboxamide
  • N-[4-(4-chlorophenyl)-1,2,5-oxadiazol-3-yl]-2-(2,3-dimethylphenoxy)acetamide
  • N-[4-(4-chlorophenyl)-1,2,5-oxadiazol-3-yl]-2-(2-methylphenoxy)acetamide
  • N-[4-(4-methoxyphenyl)-1,2,5-oxadiazol-3-yl]-2-phenoxyacetamide
  • 2-(4,6-dimethyl-1-benzofuran-3-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(furan-2-ylmethyl)acetamide
  • 7,8-dimethyl-N-[4-(morpholin-4-ylsulfonyl)phenyl]-4-oxo-4H-chromene-2-carboxamide
  • methyl 2-{[(6-methyl-4-oxo-4H-chromen-2-yl)carbonyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
  • 3-(Difluoromethyl)-3-isocyanato-2-piperidinone
  • N-{3-[(2-methoxyethyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}-7,8-dimethyl-4-oxo-4H-chromene-2-carboxamide
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