1,2-Ethanediol,1-carbamate

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Names

[ CAS No. ]:
5395-01-7

[ Name ]:
1,2-Ethanediol,1-carbamate

[Synonym ]:
HYDROXYETHYL CARBAMATE
carbamic 2-hydroxyethylester
1,2-Ethanediol,monocarbamate
Ethylene glycol monocarbamate
Carbamidsaeure-(2-hydroxy-aethylester)
Carbamic acid,2-hydroxyethyl ester
ethylene glycol carbamate
methanol,methyl carbamate
2-Hydroxyethylcarbamate

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
321.5ºC at 760mmHg

[ Melting Point ]:
43ºC

[ Molecular Formula ]:
C3H7NO3

[ Molecular Weight ]:
105.09300

[ Flash Point ]:
148.2ºC

[ Exact Mass ]:
105.04300

[ PSA ]:
72.55000

[ Index of Refraction ]:
1.463

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FB1925000
CHEMICAL NAME :
Carbamic acid, 2-hydroxyethyl ester
CAS REGISTRY NUMBER :
5395-01-7
BEILSTEIN REFERENCE NO. :
1746943
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C3-H7-N-O3
MOLECULAR WEIGHT :
105.11
WISWESSER LINE NOTATION :
ZVO2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
505 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 gm/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,1437,1982

Synthetic Route

Precursor & DownStream

Precursor

  • Ethylene carbonate
  • Ethylene glycol
  • Urea
  • Ammonia
  • Water

DownStream

  • oxazolidinone
  • 2-carbamoyloxyethyl carbamate
  • 2-Chloroethyl carbamate

Related Compounds

  • 1,2-Ethanediol,1-phenyl-, 2-carbamate
  • 1,2-Ethanediol,1-(4-fluorophenyl)-,(1R)-(9CI)
  • 1,2-Ethanediol,1-formate
  • 1,2-Ethanediol,1,2-dibenzenesulfonate
  • 1,2-Ethanediol,1,2-bis(1H-benzimidazol-2-yl)-
  • 1,2-Ethanediol,1-(4-pyridinyl)-,(1R)-(9CI)
  • 2-[4-(5-Bromo-2-ethoxybenzenesulfonyl)piperazin-1-yl]-4-methyl-6-(pyrrolidin-1-yl)pyrimidine
  • 3-(6-Methoxypyridazin-3-yl)benzoic acid
  • 4-chloro-N-(4-{[(2-ethoxyphenyl)carbamoyl]methyl}-1,3-thiazol-2-yl)benzamide
  • 2-{3-benzyl-2,4-dioxo-1H,2H,3H,4H-pyrido[3,2-d]pyrimidin-1-yl}-N-(2-ethoxyphenyl)acetamide
  • N-[1-(ethanesulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl]-2-(4-methoxyphenyl)acetamide
  • 1-(8-Methoxy-2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethanone
  • N-[1-(ethanesulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl]-3-(trifluoromethyl)benzamide
  • 2-(4-chlorophenoxy)-N-[1-(ethanesulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl]acetamide
  • N-[1-(ethanesulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl]-2-(3-methoxyphenoxy)acetamide
  • 2-bromo-N-(1-(ethylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)benzamide
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