4-Iodophenol

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Names

[ CAS No. ]:
540-38-5

[ Name ]:
4-Iodophenol

[Synonym ]:
Iodophenol
4-Hydroxyiodobenzene
4-Iodbenzolol
MFCD00002327
4-Hydroxyphenyl iodide
EINECS 208-745-5
Phenol,p-iodo
Phenol,4-iodo
p-Iodophenol
Phenol, 4-iodo-
4-iodo-phenol
para-iodophenol
p-Hydroxyiodobenzene
4-Iodophenol

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
287.2±0.0 °C at 760 mmHg

[ Melting Point ]:
92-94 °C(lit.)

[ Molecular Formula ]:
C₆H₅IO

[ Molecular Weight ]:
220.008

[ Flash Point ]:
112.4±22.6 °C

[ Exact Mass ]:
219.938507

[ PSA ]:
20.23000

[ LogP ]:
2.91

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.669

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL5600000

CHEMICAL NAME :: Phenol, p-iodo-

CAS REGISTRY NUMBER :: 540-38-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H5-I-O

MOLECULAR WEIGHT :: 220.01

WISWESSER LINE NOTATION :: QR DI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1154,1978 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7200 mg/kg/18W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,413,1959

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H312-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S22

[ RIDADR ]:
UN 3261 8/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SL5600000

[ Hazard Class ]:
8.0

[ HS Code ]:
29081900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

p-Iodobenzeneboronic acid
4-Aminophenol
1-iodo-4-prop-2-enoxybenzene
Phenol
1-iodo-4-prop-2-ynoxybenzene
4-Iodophenyl trifluoromethanesulfonate
2-(4-iodophenoxy)oxane
4-Iodophenyl acetate
4-Bromophenol
phenyl acetate

DownStream

1-[2-(4-iodophenoxy)ethyl]piperidine
(2R)-2-(4-iodophenoxy)propanoic acid
4'-Fluoro-4-biphenylol
4,4'-Difluorobiphenyl
2'-Fluoro-4-biphenylol
3'-FLUORO-[1,1'-BIPHENYL]-4-OL
Methyl p-coumarate
(4-HYDROXYMETHYL-2-PYRIDIN-3-YL-OXAZOLIDIN-4-YL)-METHANOL
4,4'-DIACETOXYBIPHENYL
2-(Chloromethyl)quinoline

Customs

[ HS Code ]: 2908199090

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

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