Propafenone
Suppliers
Names
[ CAS No. ]:
54063-53-5
[ Name ]:
Propafenone
[Synonym ]:
EINECS 258-955-6
WZ-884-643
WZ-884-642
5-OH-Propafenone-D5
Propafenone
PROPAFENONE HCL USP
MFCD00216020
Chemical & Physical Properties
[ Density]:
1.096 g/cm3
[ Melting Point ]:
171 - 174ºC
[ Molecular Formula ]:
C21H27NO3
[ Molecular Weight ]:
341.44400
[ Flash Point ]:
268ºC
[ Exact Mass ]:
341.19900
[ PSA ]:
58.56000
[ LogP ]:
3.63230
[ Index of Refraction ]:
1.557
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UC2984700
- CHEMICAL NAME :
- 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phen yl-
- CAS REGISTRY NUMBER :
- 54063-53-5
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H27-N-O3
- MOLECULAR WEIGHT :
- 341.49
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 36 mg/kg/3D-I
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis Behavioral - alteration of classical conditioning
- REFERENCE :
- JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 46,104,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 2346 mg/kg/1Y-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - sensory change involving peripheral nerve
- REFERENCE :
- MACPAJ Mayo Clinic Proceedings. (Room 1035, Plummer Bldg., Mayo Clinic, Rochester, MN 55905) V.39- 1964- Volume(issue)/page/year: 70,469,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1404 mg/kg/78D-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, allergic (after systemic exposure)
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 104,589,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 116 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - EKG changes not diagnostic of specified effects
- REFERENCE :
- AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 24,98,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 440 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,121,1991
Safety Information
[ Hazard Codes ]:
T
[ Risk Phrases ]:
R46
[ Safety Phrases ]:
53-36/37/39-45
[ WGK Germany ]:
3
[ RTECS ]:
UH2833000