Tofacitinib (CP-690550) Citrate

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Names

[ Name ]:
Tofacitinib (CP-690550) Citrate

[Synonym ]:
Tofacitinib citrate
Xeljanz
Tasocitinib citrate
3-{(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl}-3-oxopropanenitrile 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
1-Piperidinepropanenitrile, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, (3R,4R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
CP690550 citrate
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate
Tofacitinibcitrate
2-hydroxypropane-1,2,3-tricarboxylic acid,3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₈N₆O₈

[ Molecular Weight ]:
504.493

[ Exact Mass ]:
504.196869

[ PSA ]:
221.04000

[ LogP ]:
0.23418

[ Appearance of Characters ]:
white to beige

[ Storage condition ]:
room temp

[ Water Solubility ]:
DMSO: soluble5mg/mL (clear solution; warmed)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques.

Clin. Exp. Immunol. 181 , 491-510, (2015)

In this study we examined the effects of non-myeloablative total body irradiation (TBI) in combination with immunosuppressive chemotherapy on immune homeostasis in rhesus macaques. Our results show th...