Benzene-1,3-diamine dihydrochloride

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Names

[ CAS No. ]:
541-69-5

[ Name ]:
Benzene-1,3-diamine dihydrochloride

[Synonym ]:
1,3-Benzenediamine hydrochloride
Benzene-1,3-diamine hydrochloride (1:1)
m-Phenylene diamine hydrochloride
MFCD00012975
1,3-Benzenediamine hydrochloride (1:1)
benzene-1,3-diamine,dihydrochloride
1,3-Diaminobenzene Dihydrochloride
1,3-Benzenediamine, hydrochloride (1:1)
m-Phenylenediamine dihydrochloride
1,3-Phenylenediamine Dihydrochloride
EINECS 208-790-0

Chemical & Physical Properties

[ Boiling Point ]:
283.2ºC at 760 mmHg

[ Melting Point ]:
260°C (dec.)

[ Molecular Formula ]:
C₆H₉ClN₂

[ Molecular Weight ]:
144.602

[ Flash Point ]:
147.6ºC

[ Exact Mass ]:
144.045425

[ PSA ]:
52.04000

[ LogP ]:
3.61740

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
freely soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SS9800000

CHEMICAL NAME :: m-Phenylenediamine, dihydrochloride

CAS REGISTRY NUMBER :: 541-69-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H8-N2.2Cl-H

MOLECULAR WEIGHT :: 181.08

WISWESSER LINE NOTATION :: ZR CZ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/21W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 50 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,535,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,111,1978

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H317-H319-H331-H341-H410

[ Precautionary Statements ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R23/24/25;R36;R43;R50/53;R68

[ Safety Phrases ]:
S28-S36/37-S45-S60-S61-S28A

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SS9800000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2921519090

Precursor & DownStream

Precursor

DownStream

Solvent Orange 3
Benzene,1,3-diisothiocyanato-
Proflavine
2-PHENYL-2H-BENZOTRIAZOL-5-YLAMINE
1,3-Dichlorobenzene
4-[(4-nitrophenyl)azo]benzene-1,3-diamine
N-Boc-m-phenylenediamine
2-(4-METHOXY-PHENYL)-2H-BENZOTRIAZOL-5-YLAMINE
(3-hydrazinylphenyl)hydrazine
4,6-diiodobenzene-1,3-diamine

Customs

[ HS Code ]: 2921519090

[ Summary ]:
2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Enterococcus faecalis capsular polysaccharide serotypes C and D and their contributions to host innate immune evasion.

Infect. Immun. 77(12) , 5551-7, (2009)

It has become increasingly difficult to treat infections caused by Enterococcus faecalis due to its high levels of intrinsic and acquired antibiotic resistance. However, few studies have explored the ...

A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling.

Br. J. Cancer 104(10) , 1628-40, (2011)

Human breast carcinoma cells secrete an adenosine 5'-diphosphate transphosphorylase (sNDPK) known to induce endothelial cell tubulogenesis in a P2Y receptor-dependent manner. We examined sNDPK secreti...

Wide cross-reactivity between Anopheles gambiae and Anopheles funestus SG6 salivary proteins supports exploitation of gSG6 as a marker of human exposure to major malaria vectors in tropical Africa.

Malaria Journal 10 , 206, (2011)

The Anopheles gambiae gSG6 is an anopheline-specific salivary protein which helps female mosquitoes to efficiently feed on blood. Besides its role in haematophagy, gSG6 is immunogenic and elicits in e...

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2-methylbenzene-1,3-diamine dihydrochloride
4-butoxybenzene-1,3-diamine dihydrochloride
4-methylbenzene-1,3-diamine dihydrochloride
4-propoxybenzene-1,3-diamine dihydrochloride
4-dodecoxybenzene-1,3-diamine dihydrochloride
Benzoic acid, 4-[cyclohexyl[[5-[[(1-methylethyl)sulfonyl]methyl]-2-furanyl]carbonyl]amino]-3-nitro-, methyl ester
1-Propanone, 2,2-dimethyl-1-[2-(5-thiazolyl)-5-[[2-(trimethylsilyl)ethoxy]methyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl]-
rel-N-[(4R,6R)-5,6-Dihydro-6-methyl-7,7-dioxido-4H-thieno[2,3-b]thiopyran-4-yl]-N-ethyl-2-nitrobenzenesulfonamide
2-Phenylcyclopropanecarboxylic acid 2-[[2-[(2-chloro-6-fluorophenyl)methoxy]-3-methoxyphenyl]methylene]hydrazide
(4-Ethenylphenyl)methyl 5-[2-(3-ethyl-2(3H)-benzothiazolylidene)ethylidene]-4-oxo-2-thioxo-3-thiazolidineacetate
[2,3a(2)-Bifuran]-5-propanoic acid, I+/--(acetyloxy)-2,3,4,5-tetrahydro-2,5-dimethyl-, methyl ester, [2S-[2I+/-,5I+/-(R*)]]-
3-[(6-Deoxy-I+/--L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-7-(I(2)-D-xylopyranosyloxy)-4H-1-benzopyran-4-one
4H-Pyrimido[5,4-f][1,2,4]triazolo[1,5-a][1,4]diazepine-5(6H)-carboxylic acid, 9-chloro-, 1,1-dimethylethyl ester
N-[(1S,2R)-2,3-Dihydro-2-[(methylsulfonyl)oxy]-1H-inden-1-yl]-4,5,6,7-tetrahydro-1,2-benzisoxazole-3-carboxamide
8-[2-(4-Amino-2,5-dimethylphenyl)diazenyl]-5-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-2-naphthalenesulfonic acid

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