1,3-Dichlorobenzene

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Names

[ CAS No. ]:
541-73-1

[ Name ]:
1,3-Dichlorobenzene

[Synonym ]:
iazine
Benzene, 1,3-dichloro-
meta-dichlorobenzene
m-dichlorobenzene
2,4-dichloro-benzene
1,4-Dichlorobenzene
pyrimidine acid
Miazine
Pyrimidin
1,3-DIAZINE
1,3-Dichlorobenzene
2,6-dichlorobenzene
3,5-dichlorobenzene
EINECS 208-792-1
antipyrimidine
1,3-Diazin
Metadiazine
m-Diazine
MFCD00000573

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
180.4±0.0 °C at 760 mmHg

[ Melting Point ]:
-24 °C

[ Molecular Formula ]:
C₆H₄Cl₂

[ Molecular Weight ]:
147.002

[ Flash Point ]:
63.3±0.0 °C

[ Exact Mass ]:
145.969009

[ LogP ]:
3.42

[ Vapour Pressure ]:
1.2±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.549

[ Stability ]:
Stability Combustible. Incompatible with strong oxidizing agents, aluminium, aluminium alloys. Moisture-sensitive.

[ Water Solubility ]:
0.0123 g/100 mL (25 ºC)

[ Freezing Point ]:
-24℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ4499000

CHEMICAL NAME :: Benzene, m-dichloro-

CAS REGISTRY NUMBER :: 541-73-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H4-Cl2

MOLECULAR WEIGHT :: 147.00

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1062 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1470 mg/kg/10D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - changes in calcium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3330 mg/kg/90D-I

TOXIC EFFECTS :: Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg/24H

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,111,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2135 No. of Facilities: 49 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 418 (estimated) No. of Female Employees: 80 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H411

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R22;R51/53

[ Safety Phrases ]:
S61-S45-S36/37-S16-S7

[ RIDADR ]:
UN 3082 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
CZ4499000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29036990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,6-Dichlorobenzoic acid
1,2,4,5-Tetrachlorobenzene
2,4-Dichlorobenzoic acid
1,3-Dichloro-2-iodobenzene
Chlorobenzene
3-Chlorophenol
1,2,3,5-Tetrachlorobenzene
1,2,4-Trichlorobenzene
1,3,5-Trichlorobenzene

DownStream

1,3,5-trimethyl-2-[3-(2,4,6-trimethylphenyl)phenyl]benzene
1,2-bis(2,4-dichlorophenyl)prop-2-en-1-one
3,5-Dichlorobiphenyl
3-Chloro thioanisole
1,3-Bis(methylthio)benzene
2,3,3',4,5,5'-Hexachlorobiphenyl
1-Chloro-2-fluorobenzene
1,3-Difluorobenzene
1-Chloro-4-fluorobenzene
1-Chloro-3-fluorobenzene

Customs

[ HS Code ]: 2903911000

[ Summary ]:
2903911000 1,3-dichlorobenzene。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

Articles

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

[Cloning and quantitative expression of chlorocatechol 1,2-dioxygenase gene].

Huan Jing Ke Xue 30(2) , 606-9, (2009)

The chlorocatechol 1,2-dioxygenase gene, designated as tcbC (J5-2) (GenBank Accession No. EF111021), was cloned from total DNA of Pseudomonas aeruginosa J5-2 which can degrade 1,2,4-trichlorobenzene. ...

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.

J. Chromatogr. A. 1356 , 221-9, (2014)

For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromat...

1,3-dichlorobenzene-d4
2-bromo-1,3-dichlorobenzene
2,5-DIBROMO-1,3-DICHLOROBENZENE
2,5-Diamino-1,3-dichlorobenzene
2-but-3-enyl-1,3-dichlorobenzene
lithium,1,3-dichlorobenzene-2-ide
3-Chloro-2-(3-hydroxyprop-1-en-1-yl)phenol
1-(4-chloro-1-methyl-1H-imidazol-5-yl)methanamine dihydrochloride
3-(4-Chloro-2-fluorophenoxy)-3-methylazetidine
2-[1-(Aminomethyl)-3-hydroxycyclobutyl]-4-chlorophenol
2-(1-Amino-3-hydroxycyclobutyl)-4-chlorophenol
1-(2-Chloro-3,4-dimethoxyphenyl)cyclopropane-1-carbonitrile
4-(4-Chloro-2-methoxyphenyl)-2-methylbutan-2-amine
4-Chloro-2-methoxy-1-(prop-2-yn-1-yl)benzene
4-Chloro-2-nitrophenyl sulfamate
(2-Chloro-4-methoxyphenyl)methanesulfonamide

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