benzphetamine hydrochloride

Names

[ Name ]:
benzphetamine hydrochloride

[Synonym ]:
Benzphetamine hydrchloride
Benzphetaminhydrochlorid
didrex
Benzyl-methyl-((S)-1-methyl-2-phenyl-aethyl)-amin,Hydrochlorid
(+)-Benzphetamine hydrochloride
(2S)-N-benzyl-N-methyl-1-phenylpropan-2-amine hydrochloride
benzyl-methyl-((S)-1-methyl-2-phenyl-ethyl)-amine,hydrochloride
d-benzphetaminehydrochloride
Benzphetamine Hydrochloride CIII (200 mg)
BENZPHETAMINE HYDROCHLORIDE--DEA
inapetyl
(S)-BenzphetaMine Hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
334.3ºC at 760mmHg

[ Melting Point ]:
129-130°

[ Molecular Formula ]:
C₁₇H₂₂ClN

[ Molecular Weight ]:
275.81600

[ Flash Point ]:
141.5ºC

[ Exact Mass ]:
275.14400

[ PSA ]:
3.24000

[ LogP ]:
4.55160

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG9625000

CHEMICAL NAME :: Phenethylamine, N-benzyl-N,alpha-dimethyl-, hydrochloride, (+)-

CAS REGISTRY NUMBER :: 5411-22-3

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H21-N.Cl-H

MOLECULAR WEIGHT :: 275.85

WISWESSER LINE NOTATION :: R1Y1&N1&1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 2,33,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 227 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 2,33,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,15,1964

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331-H361

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T,F

[ Risk Phrases ]:
23/24/25-63-39/23/24/25-11

[ Safety Phrases ]:
22-36/37/39-45-36/37-16

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SG9625000

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Discriminative stimulus properties of intragastrically administered d-amphetamine and pentobarbital in rhesus monkeys.

J. Pharmacol. Exp. Ther. 243 , 955-962, (1987)

Rhesus monkeys were trained to discriminate intragastrically administered d-amphetamine (AMPH) or pentobarbital (PENTO) from saline using a signaled shock-avoidance trail procedure. All monkeys mainta...

Simultaneous analysis of benzphetamine and its metabolites, and quantitation of urinary p-hydroxy-N-benzylamphetamine by micellar electrokinetic chromatography.

Biol. Pharm. Bull. 21 , 1207, (1998)

We developed a method for simultaneous analysis of benzphetamine (BZ) and its metabolites, p-hydroxy-N-benzylamphetamine (pHBA), p-hydroxybenzphetamine (pHBZ), amphetamine (AP), methamphetamine and p-...