4,6-Dichloro-5-pyrimidinamine

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Names

[ CAS No. ]:
5413-85-4

[ Name ]:
4,6-Dichloro-5-pyrimidinamine

[Synonym ]:
4,6-dichloro-5-pyrimidinamin
5-AMINO-4,6-DICHLOROPYFIMIDINE
Pyrimidine, 5-amino-4,6-dichloro-
5-Amino-4,6-dichloro
5-Pyrimidinamine, 4,6-dichloro-
4,6-Dichloro-5-aminopyrimidine
5-Amino-4,6-dichloropyrimidine
4,6-Dichloro-5-pyrimidinamine
4,6-dichloropyrimidin-5-amine
5-AMino-4
4,6-dichloropyrimidine-5-amine
MFCD00006108
5-amino-4,6-dichloropyrimididne
EINECS 226-503-7
5-amino-4,6-dichloro-pyrimidine
5-amino-4,6-dichloro-4-pyrimidine

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
267.1±35.0 °C at 760 mmHg

[ Melting Point ]:
145-148 °C(lit.)

[ Molecular Formula ]:
C4H3Cl2N3

[ Molecular Weight ]:
163.99

[ Flash Point ]:
115.3±25.9 °C

[ Exact Mass ]:
162.970398

[ PSA ]:
51.80000

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29335995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4,6-Dichloro-5-nitropyrimidine
  • 5-amino-4,6-dihydroxypyrimidine

DownStream

  • 2-(2,6-Dichlorophenyl)acetonitrile
  • 7-chloro-2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidine
  • 6-Chloro-4,5-diaminopyrimidine
  • 4-Chloro-6-hydrazino-pyrimidin-5-ylamine
  • N4-Allyl-6-chloro-pyrimidine-4,5-diamine
  • 4-N-butan-2-yl-6-chloropyrimidine-4,5-diamine
  • 6-Chloro-N4-propyl-4,5-pyrimidinediamine
  • 6-Chloro-N4-methyl-4,5-pyrimidinediamine
  • 5-Aminopyrimidine
  • 6-CHLORO-N4-(4-CHLOROPHENYL)-4,5-PYRIMIDINEDIAMINE

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

6-(Alkylamino)-9-benzyl-9H-purines. A new class of anticonvulsant agents.

J. Med. Chem. 31(3) , 606-12, (1988)

Several 9-alkyl-6-substituted-purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Most compounds were prepared in three steps f...

An efficient and regiospecific strategy to N7-substituted purines and its application to a library of trisubstituted purines.

J. Comb. Chem. 8(3) , 410-6, (2006)

A regiospecific strategy for the preparation of N(7)-substituted purines in an efficient manner was devised. This approach to 6,7,8-trisubstituted purines relies on the cyclization reactions of suitab...

Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.

J. Med. Chem. 35(22) , 4180-4, (1992)

The synthesis of various chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine, (+)-EHNA, from (2S,3R)-3-amino-1,2-O-isopropylidene-1,2-nonanediol by condensation with 5-amino-4,6-dichloropyr...


More Articles

Related Compounds

  • 2-(3-CHLOROPHENYL)-4,6-DICHLORO-5-PYRIMIDINAMINE
  • 2-(4-CHLOROPHENYL)-4,6-DICHLORO-5-PYRIMIDINAMINE
  • 4,6-Dichloro-5-fluoropyrimidin-2-amine
  • 4,6-Dichloro-5-ethylpyrimidin-2-amine
  • 4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidin-2-amine
  • 4,6-Dichloro-2-ethyl-5-pyrimidinamine