flecainide

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Names

[ Name ]:
flecainide

[Synonym ]:
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
FLECAINTDE BASE
N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
2,5-bis-(2,2,2-Trifluoroethoxy)-n-(2-piperidyl-methyl)-benzamid
EINECS 200-659-6
N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
Flecainide
Benzamide,N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)
Flecanide
Flecaine
MFCD00864713

Chemical & Physical Properties

[ Density]:
1.286 g/cm3

[ Boiling Point ]:
434.9ºC at 760 mmHg

[ Melting Point ]:
105-1070C

[ Molecular Formula ]:
C₁₇H₂₀F₆N₂O₃

[ Molecular Weight ]:
414.34300

[ Flash Point ]:
216.8ºC

[ Exact Mass ]:
414.13800

[ PSA ]:
59.59000

[ LogP ]:
4.16040

[ Storage condition ]:
Refrigerator

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
7-16-36/37-45

[ RIDADR ]:
3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-piperidylmethylamine
Methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

DownStream

Articles

Multiple modes of ryanodine receptor 2 inhibition by flecainide.

Mol. Pharmacol. 86(6) , 696-706, (2014)

Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I ant...

A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.

BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)

A case of near-fatal flecainide overdose in a neonate successfully treated with sodium bicarbonate.

J. Emerg. Med. 44(4) , 781-3, (2013)

Flecainide is a class IC antidysrhythmic primarily indicated for ventricular dysrhythmias and supraventricular tachycardia (SVT). Class IC antidysrhythmic overdose has a reported mortality of 22%, and...

Flecainide
Flecainide-d3
(-)-Flecainide
(S)-Flecainide
FLECAINIDE ACETATE
flecainide acetate
4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-{methyl[(5-methyl-1,2-oxazol-3-yl)methyl]carbamoyl}butanoic acid
2-{4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentanecarbonyl]piperazin-1-yl}acetic acid
1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexanecarbonyl]-4-methylpyrrolidine-3-carboxylic acid
2-ethyl-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentanecarbonyl]-1,3-thiazolidine-4-carboxylic acid
3-ethyl-1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentanecarbonyl]pyrrolidine-3-carboxylic acid
3-{N-ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylcyclohexyl]formamido}propanoic acid
(2R)-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylcyclohexanecarbonyl]pyrrolidine-2-carboxylic acid
2-{1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1,2,5-oxadiazole-3-amido]cyclopentyl}acetic acid
2-{1-[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]cyclopentyl}acetic acid
2-{1-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-(methylsulfanyl)butanamido]cyclopentyl}acetic acid

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