2-Chloro-4H-pyrido[1,2-a]pyrimidin-4-one

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Names

[ CAS No. ]:
5418-94-0

[ Name ]:
2-Chloro-4H-pyrido[1,2-a]pyrimidin-4-one

[Synonym ]:
2-Chlor-4H-pyrido<1,2-a>pyrimidin-4-on
WLN: T66NV EMJ DG
2-cloro-4H-pirido<pirimidin-4-one
2-chloro-4H-pyrido<pyrimidin-4-one

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
287ºC at 760mmHg

[ Molecular Formula ]:
C8H5ClN2O

[ Molecular Weight ]:
180.59100

[ Flash Point ]:
127.3ºC

[ Exact Mass ]:
180.00900

[ PSA ]:
34.37000

[ LogP ]:
1.34790

[ Index of Refraction ]:
1.662

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1162000
CHEMICAL NAME :
4H-Pyrido(1,2-a)pyrimidin-4-one, 2-chloro-
CAS REGISTRY NUMBER :
5418-94-0
BEILSTEIN REFERENCE NO. :
0128192
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H5-Cl-N2-O
MOLECULAR WEIGHT :
180.60
WISWESSER LINE NOTATION :
T66NV EMJ DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03330

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 10-hydroxy-1,7-diazabicyclo[4.4.0]deca-2,4,6,9-tetraen-8-one
  • 2H-Pyrido[1,2-a]pyrimidine-2,4(3H)-dione
  • 2-Aminopyridine
  • ethyl 3-oxo-3-(pyridin-2-ylamino)propianoate
  • 2-chloro-N-phenyl-4H-pyrido[1,2-a]pyrimidin-4-imine
  • 1,2-Propadien-1-one,3-(2-pyridinylimino)-(9CI)
  • 2-(dimethylamino)-4H-pyrido[1,2-a]pyrimidin-4-one
  • phosphoryl trichloride

DownStream

  • 2-Phenyl-4H-pyrido[1,2-a]pyrimidin-4-one
  • 4-OXO-2-PIPERIDIN-1-YL-4H-PYRIDO[1,2-A]PYRIMIDINE-3-CARBALDEHYDE
  • 8-morpholin-4-yl-1,7-diazabicyclo[4.4.0]deca-2,4,6,8-tetraen-10-one
  • 2-Chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde
  • 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
  • 8-hydrazinyl-1,7-diazabicyclo[4.4.0]deca-2,4,6,8-tetraen-10-one
  • 2-aminopyrido[1,2-a]pyrimidin-4-one

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-Chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one
  • 9-Chloro-pyrido[1,2-a]pyrimidin-4-one
  • 7-chloro-2-(chloromethyl)pyrido[1,2-a]pyrimidin-4-one
  • 7-Chloro-pyrido[1,2-a]pyrimidin-4-one
  • 7-chloro-2-(chloromethyl)-6-Methylquinazolin-4(3H)-one
  • 7-Bromo-3-chloro-4H-pyrido[1,2-a]pyrimidin-4-one
  • Methyl 2-(aminomethyl)-4-fluorobutanoate
  • tert-butyl N-[2-chloro-5-(2-methylbut-3-yn-2-yl)phenyl]carbamate
  • O-[2-(5-bromopyridin-3-yl)propyl]hydroxylamine
  • Methyl 3-(2-methoxy-3-methylphenyl)-3-oxopropanoate
  • 3-Amino-3-[3-(methoxymethyl)furan-2-yl]propan-1-ol
  • Tert-butyl 4-(1-amino-2-methylpropan-2-yl)-3-methylpiperidine-1-carboxylate
  • 2-(3-Methoxy-4-nitrophenyl)propan-1-amine
  • 3-(1-Ethynylcyclopropyl)-1-benzothiophene
  • 2-Azido-2-{pyrazolo[1,5-a]pyrimidin-2-yl}ethan-1-ol
  • tert-butyl N-[2-amino-1-(4,5,6,7-tetrahydro-1H-indol-2-yl)ethyl]carbamate
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