Rilmenidine

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Names

[ CAS No. ]:
54187-04-1

[ Name ]:
Rilmenidine

[Synonym ]:
2-Oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-
Rilmenidine
S 3341-3
S 3341
N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine
Oxaminozoline
hyperium
N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
2-[N-(Dicyclopropylmethyl)amino]oxazoline
EINECS 259-021-0
Tenaxum
MFCD00865924

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
355.5±9.0 °C at 760 mmHg

[ Melting Point ]:
106 - 107ºC

[ Molecular Formula ]:
C10H16N2O

[ Molecular Weight ]:
180.247

[ Flash Point ]:
168.8±18.7 °C

[ Exact Mass ]:
180.126266

[ PSA ]:
33.62000

[ LogP ]:
0.57

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.711

[ Storage condition ]:
Store at -20°C

[ Water Solubility ]:
H2O: 7.3 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP7207400
CHEMICAL NAME :
Oxazolidine, 2-((dicyclopropylmethyl)imino)-
CAS REGISTRY NUMBER :
54187-04-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H16-N2-O
MOLECULAR WEIGHT :
180.28
WISWESSER LINE NOTATION :
T5N CO AUTJ BMY- AL3TJ&- AL3TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 umol/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,527,1983

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

[ RTECS ]:
RP7207400

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

  • N-(dicyclopropylmethyl) N'-(β-hydroxy ethyl) urea
  • 3-(2-chloroethyl)-1-(dicyclopropylmethyl)urea

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • rilmenidine
  • Rilmenidine-d4
  • Rilmenidine phosphate
  • Rilmenidine Impurity A
  • Rilmenidine hemifumarate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • 5-[(2S)-2-aminopropyl]-N,N-dimethylpyridin-2-amine