3-chloropropiononitrile

Suppliers

Names

[ CAS No. ]:
542-76-7

[ Name ]:
3-chloropropiononitrile

[Synonym ]:
nitrile of 3-chloropropionic acid
3-chloro-propionitrile
1-Chloro-2-cyanoethane
EINECS 208-827-0
MFCD00001952
3-CHLOROPROPANONITRILE
3-Chloropropiononitrile
Propanenitrile,3-chloro
USAF A-8798
Propionitrile,3-chloro

Chemical & Physical Properties

[ Density]:
1.144 g/mL at 25 °C(lit.)

[ Boiling Point ]:
174-176 °C(lit.)

[ Melting Point ]:
−52-−50 °C(lit.)

[ Molecular Formula ]:
C3H4ClN

[ Molecular Weight ]:
89.52360

[ Flash Point ]:
168 °F

[ Exact Mass ]:
89.00320

[ PSA ]:
23.79000

[ LogP ]:
1.13888

[ Index of Refraction ]:
n20/D 1.438(lit.)

[ Water Solubility ]:
4.50 g/100 mL

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UG1400000
CHEMICAL NAME :
Propionitrile, 3-chloro-
CAS REGISTRY NUMBER :
542-76-7
BEILSTEIN REFERENCE NO. :
1098454
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C3-H4-Cl-N
MOLECULAR WEIGHT :
89.53
WISWESSER LINE NOTATION :
NC2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Vascular - regional or general arteriolar or venous dilation
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571125
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,2025,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01996

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H331

[ Precautionary Statements ]:
P261-P264-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R23;R28

[ Safety Phrases ]:
S36/37/39-S45

[ RIDADR ]:
UN 3276 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UG1400000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29269095

Synthetic Route

Precursor & DownStream

Precursor

  • Acrylonitrile
  • 3-Chloropropanoyl chloride
  • hydracrylonitrile
  • 4-Chlorobutyric acid
  • propionitrile
  • 3-((2-hydroxypropan-2-yl)diazenyl)propanenitrile
  • Hydrochloric acid
  • POTASSIUM CYANIDE
  • 1-Bromo-2-chloroethane
  • Chloroform

DownStream

  • 3-[3-[(4-methoxy-3-nitro-phenyl)methyl]-2-methyl-5-nitro-imidazol-4-yl ]sulfanylpropanenitrile
  • 3-(2,4-Dihydroxyphenyl)propionic acid
  • 3-(2,6-dihydroxyphenyl)propanoic acid
  • 3-(2-CHLOROPHENYL)PROPANENITRILE
  • BENZENEPROPANENITRILE, 4-CHLORO-
  • N-(2-Cyanoethyl)pyrrole
  • 3-(4-MORPHOLINO)PROPIONITRILE
  • N-(2-Cyanoethyl)-N-methylaniline
  • 3-(4-hydroxybutoxy)propanenitrile
  • Propanenitrile,3,3'-[1,4-butanediylbis(oxy)]bis- (9CI)

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%


Related Compounds

  • 3-Amino-2-chloropropiononitrile
  • 3-benzyl-4-methyl-1,3-thiazol-3-ium,iodide
  • 3-CHLORO-4-(ISOPROPYLSULFONYL)THIOPHENE-2-CARBOXYLIC ACID
  • Cispermethrin pesticide purity reference material
  • 3-[5-(trifluoromethyl)pyridin-2-yl]benzoic acid
  • 3-(4-methoxyphenyl)-4-methylidene-3-phenyldioxolane
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • Alanine, N-(6-amino-1,4-dihydro-4-oxo-1,3,5-triazin-2-yl)-2-methyl-
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-{[1-(2-Methoxyacetyl)piperidin-4-yl]methyl}-3,4-dihydroquinazolin-4-one
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • L-Ascorbic acid, 6-O-(2-oxoethyl)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-Methyl-6-(piperidin-4-yl)pyridin-2-amine dihydrochloride
  • (S)-(1S,4R)-4-((tert-Butoxycarbonyl)amino)cyclopent-2-en-1-yl 2-acetoxy-2-phenylacetate