2,6-Dichloropurine

Names

[ Name ]:
2,6-Dichloropurine

[Synonym ]:
EINECS 226-681-6
1H-purine, 2,6-dichloro-
2,6-dichloro-7H-purine
2,6-Dichloro-1H-purine
2,6-Dichloropurine
7H-Purine, 2,6-dichloro-
MFCD00077725

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
405.4±27.0 °C at 760 mmHg

[ Melting Point ]:
185-195 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₂Cl₂N₄

[ Molecular Weight ]:
189.00

[ Flash Point ]:
231.3±9.3 °C

[ Exact Mass ]:
187.965652

[ PSA ]:
54.46000

[ LogP ]:
1.01

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.742

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
soluble

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,6-Dihydroxypurine
2-Amino-6-chloropurine
Isopentyl nitrite
1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
9H-Purin-6-ol, 1-oxide
9H-Purin-6-amine,1-oxide
N-(9-acetyl-6-chloropurin-2-yl)acetamide
Guanine
N'-(6-chloro-7H-purin-2-yl)-N,N-dimethylmethanimidamide
6-chloro-2-formylaminopurine acetate

DownStream

2-CHLORO-9-ISOPROPYL-N-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)-9H-PURIN-6-AMINE
Cladribine
2,6-Dichloropurine-2'-deoxyriboside
9H-purine-2,6-dithiol
2-Azidoadenosine
N-BENZYL-2-CHLORO-9H-PURIN-6-AMINE
2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine
SELICICLIB
N-BENZYL-2-CHLORO-9-ISOPROPYL-9H-PURIN-6-AMINE
2,6-bis(1-piperidyl)-5H-purine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines.

J. Org. Chem. 68(14) , 5773-6, (2003)

Fe-catalyzed cross-coupling reactions of 9-substituted or protected 2,6-dichloropurines with 1 equiv of methylmagnesium chloride gave regioselectively 2-chloro-6-methylpurines in good yields. The same...

Occupational contact sensitization to 2,6-dichloropurine.

Contact Dermatitis 7(6) , 349-50, (1981)