H-Leu-CMK.HCl

Names

[ CAS No. ]:
54518-92-2

[ Name ]:
H-Leu-CMK.HCl

[Synonym ]:
l-leucine chloromethyl ketone hydrochloride
MFCD00238011

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₅Cl₂NO

[ Molecular Weight ]:
200.10600

[ Exact Mass ]:
199.05300

[ PSA ]:
43.09000

[ LogP ]:
2.67000

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ HS Code ]:
2922399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Boc-Leu-chloromethylketone
(S)-(S)-2-((tert-butoxycarbonyl)amino)-4-methylpentanoic (ethyl carbonic) anhydride

DownStream

Customs

[ HS Code ]: 2922399090

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme.

J. Biol. Chem. 267 , 3811-3818, (1992)

Acylpeptide hydrolase may be involved in N-terminal deacetylation of nascent polypeptide chains and of bioactive peptides. The activity of this enzyme from human erythrocytes is sensitive to anions su...

Acetylleucine chloromethyl ketone, an inhibitor of acylpeptide hydrolase, induces apoptosis of U937 cells.

Biochem. Biophys. Res. Commun. 263 , 139-142, (1999)

Acetylleucine chloromethyl ketone (ALCK), an inhibitor of acylpeptide hydrolase (ACPH), inhibited the growth of human monoblastic U937 cells in a dose- and time-dependent manner. Morphology of the ALC...

Chloromethyl ketones are insulin-like stimulators of lipid synthesis in locust fat body.

Arch. Insect Biochem. Physiol. 39 , 9-17, (1998)

N alpha-tosyl-L-lysine chloromethyl ketone (TLCK) stimulates lipid synthesis in locust fat body in vitro, and is able to reverse the inhibitory effects of AKH-I on lipid synthesis. Effective stimulato...

H-Leu-Oall.TosOH
H-Leu-Ser-Phe-OH
H-Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMe trifluoroacetate salt
H-Leu-OTMSe
H-Leu-Leu-Tyr-OH
H-Leu-Ser-Lys-Leu-NH2 trifluoroacetate salt
benzyl (3S,5R)-3-hydroxy-5-methoxypiperidine-1-carboxylate
(2S)-3-methyl-2-[N-(2,2,2-trifluoroethyl)acetamido]butanoic acid
3,3-Dimethyl-2-[(2,2,2-trifluoroacetamido)methyl]butanoic acid
(2S)-4-methyl-2-(2,2,2-trifluoroacetamido)hexanoic acid
2,2,2-Trifluoro-1-[4-hydroxy-5-(hydroxymethyl)azepan-1-yl]ethan-1-one
2,3-Dimethyl-2-(2,2,2-trifluoroacetamido)pentanoic acid
(3R)-2,2-dimethyl-3-(2,2,2-trifluoroacetamido)pentanoic acid
2,2-Dimethyl-3-(2,2,2-trifluoroacetamido)pentanoic acid
2,3,3-Trimethyl-2-(2,2,2-trifluoroacetamido)butanoic acid
(2S)-5-methyl-2-(2,2,2-trifluoroacetamido)hexanoic acid

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