QNZ (EVP4593)

Suppliers

Names

[ Name ]:
QNZ (EVP4593)

[Synonym ]:
N-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine
6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
4,6-quinazolinediamine, N-[2-(4-phenoxyphenyl)ethyl]-
N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
QNZ
NF-kappaB Activation Inhibitor
N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine
EVP4593

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
602.0±55.0 °C at 760 mmHg

[ Melting Point ]:
169-175ºC

[ Molecular Formula ]:
C₂₂H₂₀N₄O

[ Molecular Weight ]:
356.420

[ Flash Point ]:
317.9±31.5 °C

[ Exact Mass ]:
356.163696

[ PSA ]:
73.06000

[ LogP ]:
4.57

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.714

[ Storage condition ]:
Refrigerator, Under Inert Atmosphere

[ Water Solubility ]:
DMSO: soluble15mg/mL, clear

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.

Oncotarget 6 , 9140-59, (2015)

Interstitial fluid flow and associated shear stress are relevant mechanical signals in cartilage and bone (patho)physiology. However, their effects on chondrosarcoma cell motility, invasion and metast...

Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.

Cancer Sci. 106 , 559-66, (2015)

Sirtuin 6 (SIRT6) can function as a tumor suppressor by suppressing aerobic glycolysis and apoptosis resistance. However, the negative effect of SIRT6 on cellular senescence implies that it may also h...

Hepatitis C virus NS5A drives a PTEN-PI3K/Akt feedback loop to support cell survival.

Liver Int. 35 , 1682-91, (2015)

Decreased levels of phosphatase and tensin homologue (PTEN) are associated with hepatocellular carcinoma (HCC) pathogenesis and poor prognosis in hepatitis C virus (HCV)-infected HCC patients. The mol...

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