N-Glycidylphthalimide

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Names

[ Name ]:
N-Glycidylphthalimide

[Synonym ]:
N-Glycidylphthalimide
1H-Isoindole-1,3(2H)-dione, 2-(oxiranylmethyl)-
EINECS 226-710-2
2-(oxiran-2-ylmethyl)-1H-isoindole-1,3(2H)-dione
n-(2,3-epoxypropyl)phthalimide
2-(2-Oxiranylmethyl)-1H-isoindole-1,3(2H)-dione
N-Glycidyl phthalimide
MFCD00005896
N-(2,3-Epoxypropyl)-o-Phthalimide
2-((OXIRAN-2-YL)METHYL)ISOINDOLINE-1,3-DIONE

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
347.4±15.0 °C at 760 mmHg

[ Melting Point ]:
92-98 °C(lit.)

[ Molecular Formula ]:
C₁₁H₉NO₃

[ Molecular Weight ]:
203.194

[ Flash Point ]:
163.9±20.4 °C

[ Exact Mass ]:
203.058243

[ PSA ]:
49.91000

[ LogP ]:
1.60

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.649

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI4950000

CHEMICAL NAME :: Phthalimide, N-(2,3-epoxypropyl)-

CAS REGISTRY NUMBER :: 5455-98-1

BEILSTEIN REFERENCE NO. :: 0171277

LAST UPDATED :: 199712

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C11-H9-N-O3

MOLECULAR WEIGHT :: 203.21

WISWESSER LINE NOTATION :: T56 BVNVJ C1- BT3OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4400 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,251,1979

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R41

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
TI4950000

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Potassium phthalimide
Epibromohydrin
Epichlorohydrin
1H-Isoindole-1,3(2H)-dione,2-(2-propen-1-yl)-
Glycidol
1H-Isoindole-1,3(2H)-dione,2-(3-chloro-2-hydroxypropyl)-
oxiran-2-ylmethyl 4-methyl-1-benzenesulfonate

DownStream

4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
1H-Isoindole-1,3(2H)-dione,2-(3-chloro-2-hydroxypropyl)-
2-Aminomethy-4-(4-fluorobenzyl)morpholine
N-(3-CHLORO-2-OXOPROPYL)PHTHALIMIDE
1,3-Diaminopropan-2-ol
2-(2-hydroxy-3-phenylmethoxy-propyl)isoindole-1,3-dione
1H-Isoindole-1,3(2H)-dione,2-[2-hydroxy-3-(2-nitro-1H-imidazol-1-yl)propyl]-
1-phthalimido-3-bromopropan-2-one
2-(3-bromo-2-hydroxy-propyl)isoindole-1,3-dione
ethyl 5-[(1,3-dioxoisoindol-2-yl)methyl]-2-oxo-oxolane-3-carboxylate

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

(R)-N-Glycidylphthalimide
(S)-N-Glycidylphthalimide
N-tert-butyl-3-nitroaniline
N-octanoyl benzotriazole
N,N-Dimethylcarbamic acid m-isopropylphenyl ester
N-(diaminomethylidene)pyrrolidine-1-carboximidamide,hydrochloride
4-cyano-N-((4,6-dimethoxy-1,3,5-triazin-2-yl)methyl)benzenesulfonamide
N-((4-(dimethylamino)-6-methoxy-1,3,5-triazin-2-yl)methyl)-2-methoxybenzamide
N-((4-(dimethylamino)-6-methoxy-1,3,5-triazin-2-yl)methyl)-3,4-dimethoxybenzamide
N-((4-(dimethylamino)-6-methoxy-1,3,5-triazin-2-yl)methyl)-2-(1H-indol-3-yl)acetamide
N-((4-(dimethylamino)-6-methoxy-1,3,5-triazin-2-yl)methyl)-2-(4-fluorophenyl)acetamide
(E)-N-((4-(dimethylamino)-6-methoxy-1,3,5-triazin-2-yl)methyl)-3-(furan-2-yl)acrylamide
N-{[4-(dimethylamino)-6-methoxy-1,3,5-triazin-2-yl]methyl}-2-phenylbutanamide
1-((4-(Dimethylamino)-6-methoxy-1,3,5-triazin-2-yl)methyl)-3-(2-methoxy-5-methylphenyl)urea
N-((4-(dimethylamino)-6-methoxy-1,3,5-triazin-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide
N-((4-(dimethylamino)-6-methoxy-1,3,5-triazin-2-yl)methyl)thiophene-2-sulfonamide

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