3-Cyanoindole

Names

[ Name ]:
3-Cyanoindole

[Synonym ]:
3-indolecarbonitrile
3-indolecarboxynitrile
(1H-indol-3-yl)carbonitrile
MFCD00022717
3-Cyanoindole
indole-3-carbonitrile
1H-Indole-3-carbonitrile
indole-3-acetonitrile

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
350.0±15.0 °C at 760 mmHg

[ Melting Point ]:
179-182 °C(lit.)

[ Molecular Formula ]:
C₉H₆N₂

[ Molecular Weight ]:
142.157

[ Flash Point ]:
121.9±5.6 °C

[ Exact Mass ]:
142.053101

[ PSA ]:
39.58000

[ LogP ]:
2.32

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.675

[ Storage condition ]:
Refrigerator (+4°C)

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36/37/39

[ RIDADR ]:
3439

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Indole-3-carboxaldehyde
1H-Indole-3-carboxaldehyde,oxime
Indole
N,N-Dimethylformamide
Benzyl cyanide
1H-Indole-3-carbothioamide
ALPHA-METHYLPHENYLACETONITRILE
(4-Methoxyphenyl)acetonitrile
4-Nitrophenylacetonitrile
AM0210000 [RTECS]

DownStream

methyl N-[(1-methoxyindol-3-yl)methyl]carbamodithioate
5-Bromo-1H-indole-3-carbonitrile
6-Bromo-1H-indole-3-carbonitrile
1H-Indole-3-carboxylic acid
1-benzylindole
Brassinin
1H-Indole-3-carboxamide
Indole-3-methanamine
3-CYANO-1-METHYLINDOLE
Ethyl 1H-indole-3-carboximidate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A concise synthesis of topsentin A and nortopsentins B and D.

Org. Lett. 2(14) , 2121-3, (2000)

[reaction: see text] A concise synthesis of topsentin A (R(1) = R(2) = H) and nortopsentins B (R(1) = Br, R(2) = H) and D (R(1) = R(2) = H) is described from oxotryptamine 5 via reduction of acyl cyan...

Interconversion of Nitrenes, Carbenes, and Nitrile Ylides by Ring Expansion, Ring Opening, Ring Contraction, and Ring Closure: 3-Quinolylnitrene, 2-Quinoxalylcarbene, and 3-Quinolylcarbene. Kvaskoff D, et al.

Aust. J. Chem. 62(3) , 275-86, (2009)