2-Amino-1-phenylethanone hydrochloride

Names

[ Name ]:
2-Amino-1-phenylethanone hydrochloride

[Synonym ]:
EINECS 226-787-2
Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)
2-Amino-1-phenylethanone hydrochloride (1:1)
2-amino-1-phenylethanone,hydrochloride
MFCD00012873

Chemical & Physical Properties

[ Density]:
1.084g/cm3

[ Boiling Point ]:
247.3ºC at 760mmHg

[ Melting Point ]:
194 °C (dec.)(lit.)

[ Molecular Formula ]:
C₈H₁₀ClNO

[ Molecular Weight ]:
171.624

[ Flash Point ]:
103.4ºC

[ Exact Mass ]:
171.045090

[ PSA ]:
43.09000

[ LogP ]:
2.33030

[ Storage condition ]:
Refrigerator (+4°C)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM5940000

CHEMICAL NAME :: Acetophenone, 2-amino-, hydrochloride

CAS REGISTRY NUMBER :: 5468-37-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H9-N-O.Cl-H

MOLECULAR WEIGHT :: 171.64

WISWESSER LINE NOTATION :: Z1VR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 9,203,1936

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AM5940000

[ HS Code ]:
2922399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Bromoacetophenone
2-Nitroacetophenone
2-azido-1-phenylethanone
(R)-N-tert-butanesulfinyl 2,2-dimethoxy-2-phenylethylamine
(R)-N-tert-butanesulfinyl 2-oxo-2-phenylethylamine

DownStream

4-(5-phenyl-1,3-oxazol-2-yl)benzoic acid
4-(5-phenyl-1,3-oxazol-2-yl)benzonitrile
ethyl N-(2-hydroxy-2-phenylethyl)carbamate
(5-METHYL-3-TRIFLUOROMETHYL-1H-PYRROL-2-YL)-PHENYL-METHANONE
Benzamide,N-(2-oxo-2-phenylethyl)-
1-Methylisoquinoline
2,5-Diphenyloxazole
2-naphthalen-2-yl-5-phenyl-1,3-oxazole
Oxazole,2-(2-chlorophenyl)-5-phenyl-
2-cyclohexyl-5-phenyl-1,3-oxazole

Customs

[ HS Code ]: 2922399090

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

[Anorexigenic activity of various derivatives of alpha-aminoacetophenone].

Arch. Farmacol. Toxicol. 5(3) , 165-8, (1979)

Determination of cathinone, cathine and norephedrine in hair of Yemenite khat chewers.

Forensic Sci. Int. 133(1-2) , 39-46, (2003)

A sensitive and reproducible method for the quantitative determination of cathinone (CTN), norpseudoephedrine (NPE, cathine) and norephedrine (NE) from hair was developed. The compounds were extracted...

Mechanism-based inactivation of dopamine beta-monooxygenase by beta-chlorophenethylamine.

J. Biol. Chem. 259(12) , 7772-9, (1984)

Functionalization of the beta-carbon of phenethylamines has been shown to produce a new class of substrate/inhibitor of dopamine beta-monooxygenase. Whereas both beta-hydroxy- and beta- chlorophenethy...

2-amino-1-phenylethanone hydrochloride
2-Amino-1-phenylethanone
2-amino-1-phenylethanone,hydrobromide
2-[(4-methoxyphenyl)methylamino]-1-phenylethanone,hydrochloride
2-Amino-1-phenylethanol hydrochloride
2-Amino-1-Pyrroline Hydrochloride
N-(cyanomethyl)-4-fluoro-3-methoxybenzamide
(3-Methoxyphenyl)(2,7-diazaspiro[4.4]nonan-2-yl)methanone
2,8-Diazaspiro[5.5]undecan-2-yl(tetrahydrofuran-2-yl)methanone
2-(1-Phenylcyclopentyl)ethanimidamide
Pyridin-4-yl(2,7-diazaspiro[4.4]nonan-2-yl)methanone
2-Bromo-6-fluoro-3-methylquinoline
(3-Amino-4-bromophenyl)(cyclopropyl)methanone
2-(3-Formyl-4-hydroxyphenyl)acetonitrile
1-[(3-Bromo-4-methylphenyl)methyl]piperazine
2-(3-Bromo-4-methoxyphenyl)-2-methylpropan-1-amine

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