1,4-Piperazinedicarboxylicacid, 1,4-diethyl ester

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Names

[ CAS No. ]:
5470-28-0

[ Name ]:
1,4-Piperazinedicarboxylicacid, 1,4-diethyl ester

[Synonym ]:
piperazine-1,4-dicarboxylic acid diethyl ester
Piperazin-1,4-dicarbonsaeure-diaethylester
1,4-Dicarbethoxy piperazine
1,4-Piperazinedicarboxylic acid,diethyl ester
Diethyl 1,4-piperazinedicarboxylate

Chemical & Physical Properties

[ Density]:
1.169g/cm3

[ Boiling Point ]:
315ºC at 760mmHg

[ Molecular Formula ]:
C10H18N2O4

[ Molecular Weight ]:
230.26100

[ Flash Point ]:
144.3ºC

[ Exact Mass ]:
230.12700

[ PSA ]:
59.08000

[ LogP ]:
0.79280

[ Index of Refraction ]:
1.488

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL3550000
CHEMICAL NAME :
1,4-Piperazinedicarboxylic acid, diethyl ester
CAS REGISTRY NUMBER :
5470-28-0
BEILSTEIN REFERENCE NO. :
0216109
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H18-N2-O4
MOLECULAR WEIGHT :
230.30
WISWESSER LINE NOTATION :
T6N DNTJ AVO2 DVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

Safety Information

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-Carbethoxy Piperazine
  • S-ethoxycarbonyl 4-methyl-1-piperazinecarbodithioate
  • Piperazine
  • Ethyl chloroformate

DownStream

  • N,N'-Dimethylpiperazine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1,4-Piperazinedicarboxylicacid, 2-methyl-, 1,4-diethyl ester
  • 1,4-Cyclohexanedicarboxylicacid, 1,4-diethyl ester
  • 1,4-Benzenedicarboximidicacid, 1,4-diethyl ester, hydrochloride (1:2)
  • 1,4-Piperazinedicarboxylicacid, 1,4-bis(1-methylethyl) ester
  • 1,4-Cyclohexanedicarboxylicacid, 2,5-dihydroxy-, 1,4-diethyl ester
  • 1,4-Benzenedicarboxylicacid, 2,5-diamino-, 1,4-diethyl ester
  • 1-[(5-Methyl-1,2-oxazol-3-yl)methyl]-4-[(3-methylpyridin-2-yl)methyl]piperazine
  • 5-[(2S)-3-cyclopropyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-3-methylpentanoic acid
  • N-[1-(5-bromopyridin-2-yl)piperidin-4-yl]-6-methylpyrimidin-4-amine
  • 4,4-difluoro-1-(1-{1H-pyrazolo[3,4-d]pyrimidin-4-yl}pyrrolidine-3-carbonyl)piperidine
  • 1-{Furo[3,2-c]pyridin-4-yl}-3-(piperidine-1-carbonyl)piperidine
  • 4-Amino-1-(2-methylcyclopropyl)cyclohexane-1-carboxylic acid
  • 2-[5-(cyclopropylmethyl)-1-pentyl-1H-1,2,3-triazol-4-yl]acetamide
  • 4-{3-cyclopropyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}-N-methylmorpholine-2-carboxamide
  • N-[(4-fluoro-1-{[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]methyl}piperidin-4-yl)methyl]oxolane-3-carboxamide
  • 4-[(3-fluoro-4-methoxyphenyl)methyl]-N-methylmorpholine-2-carboxamide
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