4-Nitro-2-picoline-N-oxide

Suppliers

Names

[ Name ]:
4-Nitro-2-picoline-N-oxide

[Synonym ]:
2-methyl-4-nitro-pyridine-N-oxide
2-methyl-4-nitro-1-oxidopyridin-1-ium
MFCD00014625
4-Nitro-2-methylpyridine-N-oxide
4-Nitro-2-picoline-N-oxide
Pyridine, 2-methyl-4-nitro-, 1-oxide
2-Methyl-4-nitropyridine 1-oxide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
404.0±25.0 °C at 760 mmHg

[ Melting Point ]:
155-159 °C(lit.)

[ Molecular Formula ]:
C₆H₆N₂O₃

[ Molecular Weight ]:
154.123

[ Flash Point ]:
198.1±23.2 °C

[ Exact Mass ]:
154.037842

[ PSA ]:
71.28000

[ LogP ]:
-0.09

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT5710000

CHEMICAL NAME :: Pyridine, 2-methyl-4-nitro-, 1-oxide

CAS REGISTRY NUMBER :: 5470-66-6

BEILSTEIN REFERENCE NO. :: 0135501

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H6-N2-O3

MOLECULAR WEIGHT :: 154.14

WISWESSER LINE NOTATION :: T6NJ AO B1 DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg/15W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - mouse Fibroblast

DOSE/DURATION :: 50 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,521,1975

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335-H351

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38;R40

[ Safety Phrases ]:
S22-S26-S36

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
UT5710000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

4-Amino-2-picoline
4-Methoxy-2-methylpyridine
1-hydroxy-2-methylpyridin-4-imine
2-methyl-N-[(2-methyl-1-oxopyridin-1-ium-4-ylidene)amino]-1-oxidopyridin-4-imine
4,4'-azo-bis-(2,2'-dimethylpyridine)
2,3-Dimethyl-4-nitropyridine 1-oxide
4-Chloro-2-methylpyridine
4-Bromo-pyridinecarboxylic acid
4-ethoxy-2-methylpyridine
2-methyl-3-nitropyridin-4-ol

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Redetermination of 2-methyl-4-nitro-pyridine N-oxide.

Acta Crystallogr. Sect. E Struct. Rep. Online 70(Pt 4) , o426-7, (2014)

An improved crystal structure of the title compound, C6H6N2O3, is reported. The structure, previously solved [Li et al. (1987 ▶). Jiegou Huaxue (Chin. J. Struct. Chem.), 6, 20-24] in the ortho-rhom-bi...

Mononuclear copper(II) nitrato complexes with methyl-substituted 4-nitropyridine N-oxide. Physicochemical and cytotoxic characteristics.

J. Inorg. Biochem. 104(2) , 153-60, (2010)

Three new complexes, products of the interaction of Cu(NO(3))(2) and methyl-substituted 4-nitropyridine N-oxides were synthesized and characterized by elemental analysis, magnetic, spectroscopic (IR, ...

Amination of alkyl substituted halogenopyridines with potassium amide in liquid ammonia. Van der Does L and Den Hertog HJ.

Rec. Trav. Chim. 91(12) , 1403-1413, (1972)