a d lh-rh

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Names

[ CAS No. ]:
54784-44-0

[ Name ]:
a d lh-rh

[Synonym ]:
GLP-DPHE-TRP-SER-TYR-DALA-LEU-ARG-PRO-GLY-NH2
[D-PHE2,D-ALA6]-LH-RH (HUMAN)
PYR-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
[D-PHE2,D-ALA6]-LH-RH
PGLU-D-PHE-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2
D-phe2,D-ala6-luteinizing hormone*releasing hormo
wy-18,185
LHRH,Phe(2)-Ala(6)
(d-phe(sup2))-(d-ala(sup6))-lhrh

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Molecular Formula ]:
C59H79N15O13

[ Molecular Weight ]:
1206.35000

[ Exact Mass ]:
1205.60000

[ PSA ]:
443.45000

[ LogP ]:
2.77280

[ Index of Refraction ]:
1.687

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OK6600000
CHEMICAL NAME :
Luteinizing hormone-releasing hormone, (D-phe(sup 2))-(D-ala(sup 6))-
CAS REGISTRY NUMBER :
54784-44-0
LAST UPDATED :
198910
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C59-H79-N15-O13
MOLECULAR WEIGHT :
1206.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3750 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1247,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969- Volume(issue)/page/year: 16,359,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
30 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 2,1,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
12500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 2,1,1975

Safety Information

[ Risk Phrases ]:
60

[ Safety Phrases ]:
53-22-36/37/39-45

Related Compounds

  • a-D-Glucopyranoside,methyl 6-chloro-6-deoxy-
  • A-D-GLUCOPYRANOSIDE,METHYL2-DEOXY-2-[[(PHENYLMETHOXY)CARBONYL]AMINO]-3-O-(PHENYLMETHYL)-,6-ACETATE
  • a-D-Galactopyranoside, methyl4,6-O-(phenylmethylene)-, dibenzoate (9CI)
  • a-D-Glucofuranose,1,2-O-(1-methylethylidene)-, tribenzoate (9CI)
  • a-D-Glucopyranosylazide
  • a-D-Glucofuranose,1,2:5,6-bis-O-(1-methylethylidene)-, dimethylcarbamothioate (9CI)
  • 5-(3-Methylpiperidine-1-carbonyl)-1H-pyrrole-2-carbaldehyde
  • Meluginan
  • Thiazolo[4,5-b]pyridin-5(4h)-one,7-methyl-2-(4-morpholinyl)-
  • 2-Benzyl-5-methyl-2,5-diazaspiro[3.4]octane
  • Thiazolo[4,5-b]pyridine,6-bromo-5-ethyl-2-(ethylthio)-
  • Thiazolo[4,5-b]pyridine,6-chloro-2-(ethylsulfonyl)-
  • Thiazolo[4,5-b]pyridine,6-chloro-2-(propylsulfinyl)-
  • Thiazolo[4,5-b]pyridine,6-chloro-2-[(phenylmethyl)thio]-
  • 6-Methyl-2-(methylsulfinyl)thiazolo[4,5-b]pyridine
  • 7-Benzoxazolemethanol,2-(3,4-dimethoxyphenyl)-
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