Ergoline-8-methanol,8,9-didehydro-6-methyl-

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Names

[ CAS No. ]:
548-43-6

[ Name ]:
Ergoline-8-methanol,8,9-didehydro-6-methyl-

[Synonym ]:
Elymoclavin
8,9-Didehydro-6-methylergoline-8-methanol

Chemical & Physical Properties

[ Density]:
1.247g/cm3

[ Boiling Point ]:
468ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₈N₂O

[ Molecular Weight ]:
254.32700

[ Flash Point ]:
236.8ºC

[ Exact Mass ]:
254.14200

[ PSA ]:
39.26000

[ LogP ]:
1.97820

[ Index of Refraction ]:
1.676

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KE6340000

CHEMICAL NAME :: Ergoline-8-methanol, 8,9-didehydro-6-methyl-

CAS REGISTRY NUMBER :: 548-43-6

BEILSTEIN REFERENCE NO. :: 0030650

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H18-N2-O

MOLECULAR WEIGHT :: 254.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 128 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.42- 1983- Volume(issue)/page/year: 43,1305,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 41,1700,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 58,386,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 222 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.42- 1983- Volume(issue)/page/year: 43,1305,1984 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 41,1700,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 60 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 41,1700,1975

Precursor & DownStream

Precursor

DownStream

9,10-Dihydrolysergol
[(6aR,10aR)-4,7-dimethyl-6,6a,8,10a-tetrahydroindolo[4,3-fg]quinoline-9-yl]methanol
[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methanol
Lysergol

Related Compounds

Ergoline-8-methanol,8,9-didehydro-6-methyl-1-phenyl
[(6aR,10aR)-7-ethyl-6,6a,8,10a-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methanol
[(6aR,10aR)-7-propyl-6,6a,8,10a-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methanol
[(6aR,10aR)-4,7-dimethyl-6,6a,8,10a-tetrahydroindolo[4,3-fg]quinoline-9-yl]methanol
[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]methanol
(6aR,10aR)-7-methyl-6,6a,8,10a-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxylic acid
2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoropropanamido]-3,3,3-trifluoro-2-methylpropanoic acid
(3R)-3-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]butanoic acid
(3R)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxypropanamido]butanoic acid
(3R)-3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-phenylpropanamido]butanoic acid
(3R)-3-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]formamido}butanoic acid
5-Amino-1-[3-(dimethylamino)-2-hydroxypropyl]-1,2-dihydropyridin-2-one
(2S)-2-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]-4-(methylsulfanyl)butanoic acid
2-[(3S)-N-[2-(dimethylamino)ethyl]-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]acetic acid
1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanoyl]-3,5-dimethylpiperidine-2-carboxylic acid
3-[3-(benzyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-3-cyclobutylpropanoic acid

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