Tris(4-aminophenyl)methane

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Names

[ CAS No. ]:
548-61-8

[ Name ]:
Tris(4-aminophenyl)methane

[Synonym ]:
EINECS 208-952-0
4-[bis(4-aminophenyl)methyl]aniline
Tris(4-aminophenyl)methane

Chemical & Physical Properties

[ Density]:
1.208g/cm3

[ Boiling Point ]:
540.9ºC at 760mmHg

[ Molecular Formula ]:
C19H19N3

[ Molecular Weight ]:
289.37400

[ Flash Point ]:
316.7ºC

[ Exact Mass ]:
289.15800

[ PSA ]:
78.06000

[ LogP ]:
5.35700

[ Index of Refraction ]:
1.701

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB7350000
CHEMICAL NAME :
Methane, tris(4-aminophenyl)-
CAS REGISTRY NUMBER :
548-61-8
BEILSTEIN REFERENCE NO. :
2811314
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C19-H19-N3
MOLECULAR WEIGHT :
289.41
WISWESSER LINE NOTATION :
ZR DYR DZ&R DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,485,1986 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26 gm/kg/47W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - tumors Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg/90W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - tumors Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
64 gm/kg/64W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6880 mg/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 gm/kg/39W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(9),66,1976

Safety Information

[ Hazard Codes ]:
T+

[ RIDADR ]:
2811.0

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ci 42500
  • Pararosaniline Hydrochloride
  • Aurin
  • Anilinium chloride
  • Formaldehyde
  • N-Phenylhydroxylamine
  • Formamide, N-phenyl-
  • 1-[bis(4-nitrophenyl)methyl]-4-nitro-benzene

DownStream

  • ci 42500
  • [4-[bis[4-(trimethylazaniumyl)phenyl]methyl]phenyl]-trimethylazanium,triiodide
  • TRIS(4-CHLOROPHENYL)METHANE
  • Triphenylmethane

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

  • Tris(4-Aminophenyl)amine
  • tris(4-aminophenyl) phosphate
  • Tris-(4-aminophenyl)thiophosphat
  • tetrakis(4-aminophenyl)methane
  • Tetrakis(4-aminophenyl)methane
  • aniline,tris(4-aminophenyl)methanol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1,3-Dihydro-5-methyl-6-nitro-2H-benzimidazole-2-thione
  • 4-Amino-3-(4-cyclopropylphenyl)butanoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • Dodecyl[(5-hydroxy-4-oxo-4H-pyran-2-yl)methyl]dimethylammonium chloride
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • N-(4-amino-2-((2-((benzo[d][1,3]dioxol-5-ylmethyl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-ethoxybenzamide