1H-Benz[de]isoquinoline-1,3(2H)-dione,2-[2-(dimethylamino)ethyl]-5-nitro-

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Names

[ CAS No. ]:
54824-17-8

[ Name ]:
1H-Benz[de]isoquinoline-1,3(2H)-dione,2-[2-(dimethylamino)ethyl]-5-nitro-

[Synonym ]:
2-(2-(dimethylamino)ethyl)-3-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione
Mitonafidum [INN-Latin]
Mitonafida [INN-Spanish]
M 4212 (Pharmaceutical)
2-(2-(dimethylamino) ethyl)-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione
N-(2-(Dimethylamino)ethyl)-3-nitronaphthalimide
M-4212
2-(2-dimethylaminoethyl)-5-nitrobenzo[de]isoquinoline-1,3-dione
Mitonafide

Chemical & Physical Properties

[ Density]:
1.384g/cm3

[ Boiling Point ]:
496.8ºC at 760 mmHg

[ Molecular Formula ]:
C16H15N3O4

[ Molecular Weight ]:
313.30800

[ Flash Point ]:
254.3ºC

[ Exact Mass ]:
313.10600

[ PSA ]:
88.13000

[ LogP ]:
1.94570

[ Index of Refraction ]:
1.667

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QK5650000
CHEMICAL NAME :
Naphthalimide, 2-(2-(dimethylamino)ethyl)-5-nitro-
CAS REGISTRY NUMBER :
54824-17-8
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C16-H15-N3-O4
MOLECULAR WEIGHT :
313.34
WISWESSER LINE NOTATION :
T666 1A M CVNVJ D2N1&1 HNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6500 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10000 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
4 mg/L
REFERENCE :
CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 4,61,1980

Safety Information

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

  • 5-Nitro-1H,3H-benzo[de]isochromene-1,3-dione
  • 1,1-Dimethylethylenediamine

DownStream

  • Amonafide
  • N-[2-(Dimethylamino)ethyl]-3-(acetylamino)-1,8-naphthalenedicarbimide
  • 1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-(2-(dimethylamino)ethyl)-

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-((5-(furan-2-yl)pyridin-3-yl)methyl)-2-(pyridin-3-yl)acetamide
  • N-((5-(furan-2-yl)pyridin-3-yl)methyl)-2-(thiophen-3-yl)acetamide
  • N-((5-(furan-2-yl)pyridin-3-yl)methyl)tetrahydrofuran-3-carboxamide
  • N-((5-(furan-2-yl)pyridin-3-yl)methyl)-3-(methylthio)benzamide
  • 3-fluoro-N-((5-(furan-2-yl)pyridin-3-yl)methyl)-4-methoxybenzamide
  • N-((5-(furan-2-yl)pyridin-3-yl)methyl)-3-(1H-pyrazol-1-yl)benzamide
  • N-((5-(furan-2-yl)pyridin-3-yl)methyl)-1,3,5-trimethyl-1H-pyrazole-4-carboxamide
  • 1-(4-fluorophenyl)-N-((5-(furan-2-yl)pyridin-3-yl)methyl)cyclopropanecarboxamide
  • N-((5-(furan-2-yl)pyridin-3-yl)methyl)morpholine-4-carboxamide
  • Pyridin-2-ylmethyl ((5-(furan-2-yl)pyridin-3-yl)methyl)carbamate
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