b-Yohimbine

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Names

[ CAS No. ]:
549-84-8

[ Name ]:
b-Yohimbine

[Synonym ]:
Methyl (16α,17β)-17-hydroxyyohimban-16-carboxylate
Yohimban-16α-carboxylic acid, 17β-hydroxy-, methyl ester
Yohimban-16-α-carboxylic acid, 17-β-hydroxy-, methyl ester
.beta.-Yohimbine
Amsonin
Yohimban-16α-carboxylic acid, 17β-hydroxy-, methyl ester (8CI)
Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17β)-
Amsonine
b-Yohimbine
β-Yohimbine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
543.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H26N2O3

[ Molecular Weight ]:
354.443

[ Flash Point ]:
282.2±30.1 °C

[ Exact Mass ]:
354.194336

[ PSA ]:
65.56000

[ LogP ]:
2.20

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.661

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZG1000030
CHEMICAL NAME :
Yohimban-16-alpha-carboxylic acid, 17-beta-hydroxy-, methyl ester
CAS REGISTRY NUMBER :
549-84-8
LAST UPDATED :
199007
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C21-H26-N2-O3
MOLECULAR WEIGHT :
354.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,317,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
68 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5400 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

  • Yohimbine

Related Compounds

  • B-Nor-5β-cholestan-3-one ethylene acetal
  • 3-O-methyl 5-O-[2-(methylamino)-1-phenylpropyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate,hydrochloride
  • B-(10-[1,1'-Biphenyl]-4-yl-9-anthracenyl)boronic acid
  • b-Alanine, N,N-diethyl-
  • B-cyclohexylcatecholborane
  • B-SITOSTERONE
  • 3-Pentan-3-ylbicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-(2-Ethoxyethyl)bicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-(4-Methoxybutyl)bicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-Benzylbicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-[2-(2-Methoxyethoxy)ethyl]bicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-[(2-Chlorophenyl)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-[(2,5-Difluorophenyl)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid
  • 3-Cyclopropylbicyclo[1.1.1]pentan-1-amine
  • 3-Propylbicyclo[1.1.1]pentan-1-amine
  • 3-Cyclobutylbicyclo[1.1.1]pentan-1-amine
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