Dibenamine hydrochloride

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Names

[ CAS No. ]:
55-43-6

[ Name ]:
Dibenamine hydrochloride

[Synonym ]:
N,N-dibenzyl-2-chloroethanamine,hydrochloride
MFCD00012518
EINECS 200-234-5

Chemical & Physical Properties

[ Density]:
1.107g/cm3

[ Boiling Point ]:
320ºC at 760mmHg

[ Melting Point ]:
190-193 °C(lit.)

[ Molecular Formula ]:
C16H19Cl2N

[ Molecular Weight ]:
296.23500

[ Flash Point ]:
147.3ºC

[ Exact Mass ]:
295.08900

[ PSA ]:
3.24000

[ LogP ]:
4.72960

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HQ6825000
CHEMICAL NAME :
Dibenzylamine, N-(2-chloroethyl)-, hydrochloride
CAS REGISTRY NUMBER :
55-43-6
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H18-Cl-N.Cl-H
MOLECULAR WEIGHT :
296.26
WISWESSER LINE NOTATION :
G2N1R&1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
HQ6825000

[ HS Code ]:
2921499090

Precursor & DownStream

Precursor

DownStream

  • N,N-Dibenzyl-2-chloroethanamine

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine).

Biochem. Pharmacol. 23(10) , 1479-91, (1974)

Effect of dibenamine (N-(2-chloroethyl) dibenzylamine) on the metabolism of radioactive epinephrine.

J. Biol. Chem. 202(1) , 39-43, (1953)


More Articles

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