hydrocotarnine

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Names

[ CAS No. ]:
550-10-7

[ Name ]:
hydrocotarnine

[Synonym ]:
8-methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
Hydrocotarnine

Chemical & Physical Properties

[ Boiling Point ]:
342.4ºC at 760 mmHg

[ Molecular Formula ]:
C12H15NO3

[ Molecular Weight ]:
221.25200

[ Flash Point ]:
106.7ºC

[ Exact Mass ]:
221.10500

[ PSA ]:
30.93000

[ LogP ]:
1.34970

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JI4825000
CHEMICAL NAME :
1,3-Dioxolo(4,5-g)isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-
CAS REGISTRY NUMBER :
550-10-7
BEILSTEIN REFERENCE NO. :
0017283
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H15-N-O3
MOLECULAR WEIGHT :
221.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 15,111,1960
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 15,111,1960

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-4-ol
  • Acetic acid 8-methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-4-yl ester
  • 5,6,7,8-Tetrahydro-8-ethoxy-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline
  • N-(2-methoxy-3,4-methylenedioxybenzyl)-N-(p-toluene-sulfonyl)aminoacetaldehyde diethylacetal
  • 4-Methoxy-1,3-benzodioxole-5-carbaldehyde
  • [N-[2-Methoxy-3,4-(methylenedioxy)benzyl]amino]acetaldehyde diethyl acetal
  • [N-[2-Methoxy-3,4-(methylenedioxy)benzyl]-N-methylamino]acetaldehyde diethyl acetal
  • cotarnine
  • 1,3-dimethylbarbituric acid

DownStream

  • 4-methoxy-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium,iodide
  • Meconine
  • 2-Methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
  • 2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
  • 1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7, 8-tetrahydro-6-methyl-

Related Compounds

  • Hydrocotarnine HCl
  • Hydrocotarnine methiodide
  • Hydrocotarnine hydriodide
  • Hydrocotarnine hemihydrate
  • Hydrocotarnine methobromide
  • Hydrocotarnine hydrobromide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 2-((1-Cyclopentyl-1h-tetrazol-5-yl)thio)propanenitrile
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • Phenyl 4-{[2-(naphthalen-1-yl)acetamido]methyl}piperidine-1-carboxylate
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine