Salsalate
Suppliers
Names
[ CAS No. ]:
552-94-3
[ Name ]:
Salsalate
[Synonym ]:
Disalcid
EINECS 209-027-4
2-[(2-Hydroxybenzoyl)oxy]benzoic acid
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
2-(2-hydroxybenzoyl)oxybenzoic acid
2-salicyloyloxy-benzoic acid
Salicylsalicylic acid
Saloxium
Diacesal
Salicylic Acid Bimolecular Ester
Disalicylic acid
Salicyl salicylate
2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid
Diplosal
Salina
Salicylic Acid Salicylate
carboxyphenyl salicylate
Disalyl
MFCD00020252
Salsalate
sasapyrine
Sasapyrinum
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
482.9±25.0 °C at 760 mmHg
[ Melting Point ]:
139-151 °C
[ Molecular Formula ]:
C14H10O5
[ Molecular Weight ]:
258.226
[ Flash Point ]:
188.0±16.7 °C
[ Exact Mass ]:
258.052826
[ PSA ]:
83.83000
[ LogP ]:
3.05
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.646
[ Storage condition ]:
room temp
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DH2080000
- CHEMICAL NAME :
- Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
- CAS REGISTRY NUMBER :
- 552-94-3
- BEILSTEIN REFERENCE NO. :
- 2590908
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C14-H10-O5
- MOLECULAR WEIGHT :
- 258.24
- WISWESSER LINE NOTATION :
- QVR BOVR BQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 2229 mg/kg/2Y-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 107,116,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1020 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1101,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 665 mg/kg
- SEX/DURATION :
- female 17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 29,250,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80509 No. of Facilities: 105 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3179 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80509 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 629 (estimated) No. of Female Employees: 291 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H400
[ Precautionary Statements ]:
P301 + P312 + P330
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
37/39-26
[ RIDADR ]:
3077.0
[ RTECS ]:
DH2080000
[ HS Code ]:
2918230000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918990090
[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
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Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both a...
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