AP-18

Suppliers

Names

[ Name ]:
AP-18

[Synonym ]:
(2E,3E)-4-(4-Chlorophenyl)-N-hydroxy-3-methyl-3-buten-2-imine
(2E,3E)-4-(4-Chlorophenyl)-N-hydroxy-3-methylbut-3-en-2-imine
3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime, (2E,3E)-
N-Desmethylclozapine
4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime
AP-18

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
348.4±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₂ClNO

[ Molecular Weight ]:
209.672

[ Flash Point ]:
164.5±25.7 °C

[ Exact Mass ]:
209.060745

[ PSA ]:
32.59000

[ LogP ]:
3.72

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.529

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Articles

TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide.

PLoS ONE 7(10) , e46917, (2012)

Hydrogen sulfide (H(2)S), which is produced endogenously from L-cysteine, is an irritant with pro-nociceptive actions. We have used measurements of intracellular calcium concentration, electrophysiolo...

TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice.

PLoS ONE 4 , e7596, (2009)

Nitric oxide (NO) can induce acute pain in humans and plays an important role in pain sensitization caused by inflammation and injury in animal models. There is evidence that NO acts both in the centr...

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis.

Arthritis Rheum. 63 , 819-29, (2011)

To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in inflammatory hyperalgesia mediated by tumor necrosis factor α(TNFα) and joint inflammation.Mechanical hyperalgesia w...

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