N,N-bis-(2-Chloroethyl)aniline
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Names
[ CAS No. ]:
553-27-5
[ Name ]:
N,N-bis-(2-Chloroethyl)aniline
[Synonym ]:
Lymphoquine
Aniline mustard
Mesylerythrol
Lymphocin
Lymphochin
Lymphoquin
Lymphchin
Chemical & Physical Properties
[ Density]:
1.19 g/cm3
[ Boiling Point ]:
304.1ºC at 760 mmHg
[ Molecular Formula ]:
C10H13Cl2N
[ Molecular Weight ]:
218.12300
[ Flash Point ]:
137.7ºC
[ Exact Mass ]:
217.04300
[ PSA ]:
3.24000
[ LogP ]:
2.97060
[ Index of Refraction ]:
1.563
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BW8225000
- CHEMICAL NAME :
- Aniline, N,N-bis(2-chloroethyl)-
- CAS REGISTRY NUMBER :
- 553-27-5
- BEILSTEIN REFERENCE NO. :
- 0880463
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C10-H13-Cl2-N
- MOLECULAR WEIGHT :
- 218.14
- WISWESSER LINE NOTATION :
- G2NR&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 239 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 123 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/m3/10M
- TOXIC EFFECTS :
- Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 52 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 375 mg/kg/35D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 375 mg/kg/15D-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 30 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,78,1984
Safety Information
[ Hazard Codes ]:
C
[ HS Code ]:
2921420090
Synthetic Route
Customs
[ HS Code ]: 2921420090
[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%