N,N-bis-(2-Chloroethyl)aniline

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Names

[ CAS No. ]:
553-27-5

[ Name ]:
N,N-bis-(2-Chloroethyl)aniline

[Synonym ]:
Lymphoquine
Aniline mustard
Mesylerythrol
Lymphocin
Lymphochin
Lymphoquin
Lymphchin

Chemical & Physical Properties

[ Density]:
1.19 g/cm3

[ Boiling Point ]:
304.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₃Cl₂N

[ Molecular Weight ]:
218.12300

[ Flash Point ]:
137.7ºC

[ Exact Mass ]:
217.04300

[ PSA ]:
3.24000

[ LogP ]:
2.97060

[ Index of Refraction ]:
1.563

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BW8225000

CHEMICAL NAME :: Aniline, N,N-bis(2-chloroethyl)-

CAS REGISTRY NUMBER :: 553-27-5

BEILSTEIN REFERENCE NO. :: 0880463

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C10-H13-Cl2-N

MOLECULAR WEIGHT :: 218.14

WISWESSER LINE NOTATION :: G2NR&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 239 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 123 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/m3/10M

TOXIC EFFECTS :: Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 375 mg/kg/35D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 375 mg/kg/15D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 30 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,78,1984

Safety Information

[ Hazard Codes ]:
C

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

N,N-bis(2-chloroethyl)aniline,hydrochloride
N,N-bis(2-chloroethyl)aniline,carbon monoxide,chromium
4-chloro-N,N-bis(2-chloroethyl)aniline
4-butyl-N,N-bis(2-chloroethyl)aniline
4-arsoroso-N,N-bis(2-chloroethyl)aniline
4-(2-aminoethoxy)-N,N-bis(2-chloroethyl)aniline
1-(2-Chlorophenyl)-N-{2-[4-(dimethylamino)phenyl]-2-hydroxyethyl}methanesulfonamide
3-chloro-N-{2-[4-(dimethylamino)phenyl]-2-hydroxyethyl}-4-fluorobenzene-1-sulfonamide
N-(2-(4-(dimethylamino)phenyl)-2-hydroxyethyl)-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
N-(3-(6-oxopyridazin-1(6H)-yl)propyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamide
methyl 3-(6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamido)thiophene-2-carboxylate
(6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl)(3-hydroxyazetidin-1-yl)methanone
N-(2-((1H-indol-3-yl)thio)ethyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamide
N-((2-methyl-1H-indol-5-yl)methyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamide
N-((1-ethylpyrrolidin-2-yl)methyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamide
N-((2-oxo-3-phenyloxazolidin-5-yl)methyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamide

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