Benzenemethanol, a-[(2-pyridinylamino)methyl]-

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Names

[ CAS No. ]:
553-69-5

[ Name ]:
Benzenemethanol, a-[(2-pyridinylamino)methyl]-

[Synonym ]:
Miodar
Vilexin
1-phenyl-2-pyridin-2-ylamino-ethanol
Analexin
Cabral
Evasprine
MJ 505
IN 511
Abbolexin
Bonapar
Evasprin

Chemical & Physical Properties

[ Density]:
1.206g/cm3

[ Boiling Point ]:
383.2ºC at 760mmHg

[ Molecular Formula ]:
C13H14N2O

[ Molecular Weight ]:
214.26300

[ Flash Point ]:
185.5ºC

[ Exact Mass ]:
214.11100

[ PSA ]:
45.15000

[ LogP ]:
2.30010

[ Index of Refraction ]:
1.647

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DP1050000
CHEMICAL NAME :
Benzyl alcohol, alpha-((2-pyridylamino)methyl)-
CAS REGISTRY NUMBER :
553-69-5
BEILSTEIN REFERENCE NO. :
0169969
LAST UPDATED :
199706
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C13-H14-N2-O
MOLECULAR WEIGHT :
214.29
WISWESSER LINE NOTATION :
T6NJ BM1YQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
756 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 130,280,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 103,245,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
355 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 141,83,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
405 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,247,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
124 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 141,83,1963

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Styrene oxide
  • 2-Aminopyridine
  • 2,2-Dihydroxy-1-phenylethan-1-one
  • 1,3-Dioxolane,2-(bromomethyl)-2-phenyl-
  • 2-Bromopyridine
  • phenylethanolamine

DownStream

  • 3-phenyl-2,3-dihydroimidazo[1,2-a]pyridine

Related Compounds

  • Benzenemethanol, a-[(2-pyridinylamino)methyl]-,hydrochloride (1:1)
  • Benzenemethanol, 4-methyl-alpha-[(2-pyridinylamino)methyl]- (9CI)
  • Benzenemethanol, a-[(2-methoxyethoxy)methyl]-
  • Benzenemethanol, a-[(2-ethoxyethoxy)methyl]-
  • Benzenemethanol, a-[(2-pyrimidinylamino)methyl]-,hydrochloride (1:1)
  • Benzenemethanol, a-[[2-(dimethylamino)ethoxy]methyl]-a-phenyl-,hydrochloride (9CI)
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-(2-Ethyl-1-hydroxybutan-2-yl)-4,4-difluorocyclohexan-1-ol
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-[5-bromo-2-(prop-2-yn-1-yloxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • Ethyl 3-(3-{3-amino-1-azabicyclo[2.2.2]octan-3-yl}-1,2,4-oxadiazol-5-yl)propanoate
  • 2-Methyl-4-{pyrazolo[1,5-a]pyridin-3-yl}butan-2-amine
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide