(S)-(−)-Warfarin

Suppliers

Names

[ Name ]:
(S)-(−)-Warfarin

[Synonym ]:
2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-
S-(−)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one
Warfarin
2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-
EINECS 226-908-9
(R)-Warfarin
4-Hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-chromen-2-one
(R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
R-(+)-Warfarin
(-)-Warfarin
(S)-Warfarin
(R)-(+)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
MFCD00272376
2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (S)-
(R)-(+)-WARFARIN
2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (R)-
(+)-Warfarin
(S)-(-)-Warfarin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
515.2±50.0 °C at 760 mmHg

[ Melting Point ]:
≥170ºC

[ Molecular Formula ]:
C₁₉H₁₆O₄

[ Molecular Weight ]:
308.328

[ Flash Point ]:
188.8±23.6 °C

[ Exact Mass ]:
308.104858

[ PSA ]:
67.51000

[ LogP ]:
3.42

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.635

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360D-H372-H412

[ Precautionary Statements ]:
P201-P273-P308 + P313

[ Hazard Codes ]:
T

[ Risk Phrases ]:
61-48/25-52/53

[ Safety Phrases ]:
53-45-61

[ RIDADR ]:
UN 2811 6.1/PG 1

Articles

Hologram QSAR model for the prediction of human oral bioavailability.

Bioorg. Med. Chem. 15 , 7738-45, (2007)

A drug intended for use in humans should have an ideal balance of pharmacokinetics and safety, as well as potency and selectivity. Unfavorable pharmacokinetics can negatively affect the clinical devel...

Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes.

J. Thromb. Haemost. 8(12) , 2708-17, (2010)

Warfarin, an antagonist of vitamin K, is an oral coumarin anticoagulant widely used to control and prevent thromboembolic disorders. Warfarin is clinically available as a racemic mixture of R- and S-w...

Secreted protein profile from HepG2 cells incubated by S(-) and R(+) enantiomers of chiral drug warfarin - An analysis in cell-based system and clinical samples.

Proteomics. Clin. Appl. 4(10-11) , 808-15, (2010)

warfarin is a commonly prescribed oral anticoagulant with narrow therapeutic index. It interferes with the vitamin K cycle to achieve anti-coagulating effects. Warfarin has two enantiomers, S(-) and R...