Iprozilamine

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Names

[ CAS No. ]:
55477-19-5

[ Name ]:
Iprozilamine

[Synonym ]:
Iprozilamine [INN]
[4-chloro-6-(4-methyl-piperazin-1-yl)-5-methylsulfanyl-pyrimidin-2-yl]-isopropyl-amine
Iprozilamina [INN-Spanish]
Iprozilaminum
4-Chloro-2-isopropylamino-6-(4-methylpiperazino)-5-methylthiopyrimidine
2-Isopropylamino-4-(4-methylpiperazino)-5-methylmercapto-6-chlorpyrimidin
Pyrimidine,4-chloro-2-isopropylamino-6-(4-methylpiperazino)-5-methylthio
Iprozilaminum [INN-Latin]
Iprozilamina
Iprozilamine
2-Isopropylamino-4-methylpiperazino-6-chloro-5-methylthio-pyrimidine

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
449.7ºC at 760 mmHg

[ Molecular Formula ]:
C13H22ClN5S

[ Molecular Weight ]:
315.86500

[ Flash Point ]:
225.8ºC

[ Exact Mass ]:
315.12800

[ PSA ]:
69.59000

[ LogP ]:
2.49990

[ Index of Refraction ]:
1.605

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV8111000
CHEMICAL NAME :
Pyrimidine, 4-chloro-2-isopropylamino-6-(4-methylpiperazino)-5-me thylthio-
CAS REGISTRY NUMBER :
55477-19-5
BEILSTEIN REFERENCE NO. :
0674548
LAST UPDATED :
199703
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H22-Cl-N5-S
MOLECULAR WEIGHT :
315.91
WISWESSER LINE NOTATION :
T6N DNTJ A1 D- DT6N CNJ BMY1&1 ES1 FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
455 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,553,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,553,1975

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methylpiperazine
  • 4,6-dichloro-N-isopropyl-5-(methylthio)pyrimidin-2-amine

DownStream

Related Compounds

  • 1-{[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]methyl}cyclobutane-1-carboxylic acid
  • 1-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]-2-methylpiperidine-4-carboxylic acid
  • 1-ethyl-5',6'-dihydro-4'H-spiro[pyrrolidine-3,7'-thieno[2,3-c]pyridine]
  • 5,5-dimethyl-5',6'-dihydro-4'H-spiro[oxolane-3,7'-thieno[2,3-c]pyridine]
  • 5',6'-dihydro-4'H-spiro[cycloheptane-1,7'-thieno[2,3-c]pyridine]
  • 7-(butan-2-yl)-7-methyl-4H,5H,6H,7H-thieno[2,3-c]pyridine
  • 5-Ethyl-3',5',6',7'-tetrahydrospiro[cyclohexane-1,4'-imidazo[4,5-c]pyridine]
  • 2-[2-(4-methanesulfonyl-1H-pyrazol-1-yl)ethyl]morpholine
  • N-propyl-2H-indazole-7-sulfonamide
  • rac-tert-butyl (3R,4S)-3-(3,4-dihydro-2H-pyran-6-yl)-4-hydroxypyrrolidine-1-carboxylate
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