3-Hydroxy-alpha-methyl-DL-tyrosine
Suppliers
Names
[ CAS No. ]:
555-29-3
[ Name ]:
3-Hydroxy-alpha-methyl-DL-tyrosine
[Synonym ]:
a-Methyl-L-dopa
α-Methyl-L-dopa
Dopegyt
EINECS 209-088-7
3-(3,4-Dihydroxyphenyl)-2-methyl alanine
L-(-)-b-(3,4-Dihydroxyphenyl)-a-methylalanine
L-(-)-α-Methyl-β-(3,4-dihydroxyphenyl)alanine
L-(-)-a-Methyl-b-(3,4-dihydroxyphenyl)alanine
rac Alpha-Methyl DOPA
2-Methyl-3-(3,4-dihydroxyphenyl)-DL-alanine
a-Methyl Dopa
(+)-α-Methyldopa
Mulfasin
UNII:33TD13T99R
α-Methyl dopa
3-Hydroxy-α-methyltyrosine
Metholes
Tyrosine, 3-hydroxy-α-methyl-
L-(a-Md)
L-α-Methyldopa
(-)-α-Methyldopa
3-Hydroxy-α-methyl-L-tyrosine
L-Tyrosine, 3-hydroxy-α-methyl-
Dopamet
(S)-(-)-a-Methyldopa
a-Methyl-b-(3,4-dihydroxyphenyl)-L-alanine
Bayer 1440L
MFCD00065917
Methyl dopa
Aldomet
l-a-Methyldopa
(S)-a-Methyldopa
ALDORIL
Alanine, 3- (3,4-dihydroxyphenyl)-2-methyl-, L-
Methyldopa
L-a-Methyl-3,4-dihydroxyphenylalanine
(-)-Methyldopa
Elanpres
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
441.6±45.0 °C at 760 mmHg
[ Molecular Formula ]:
C10H13NO4
[ Molecular Weight ]:
211.214
[ Flash Point ]:
220.9±28.7 °C
[ Exact Mass ]:
211.084457
[ PSA ]:
103.78000
[ LogP ]:
0.13
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.635
[ Storage condition ]:
−20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AY5940000
- CHEMICAL NAME :
- Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, DL-
- CAS REGISTRY NUMBER :
- 555-29-3
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H13-N-O4
- MOLECULAR WEIGHT :
- 211.24
- WISWESSER LINE NOTATION :
- QVXZ1&1R CQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5710 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 430 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5370 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1317 mg/kg
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1318,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1760 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36
[ Safety Phrases ]:
26-36/37
[ WGK Germany ]:
3