8-Methyl-10H-pyrido(3,2-b)pyrimido(4,5-e)(1,4)thiazin-4-amine

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Names

[ CAS No. ]:
55740-63-1

[ Name ]:
8-Methyl-10H-pyrido(3,2-b)pyrimido(4,5-e)(1,4)thiazin-4-amine

[Synonym ]:
4-Amino-8-methyl-1,3,9-triazaphenotriazin
4-Amino-8-methyl-1,3,9-triazaphenothiazin

Chemical & Physical Properties

[ Density]:
1.447g/cm3

[ Boiling Point ]:
486.4ºC at 760 mmHg

[ Molecular Formula ]:
C10H9N5S

[ Molecular Weight ]:
231.27700

[ Flash Point ]:
248ºC

[ Exact Mass ]:
231.05800

[ PSA ]:
105.25000

[ LogP ]:
1.40910

[ Index of Refraction ]:
1.733

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1173100
CHEMICAL NAME :
10H-Pyrido(3,2-b)pyrimido(4,5-e)(1,4)thiazin-4-amine, 8-methyl-
CAS REGISTRY NUMBER :
55740-63-1
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H9-N5-S
MOLECULAR WEIGHT :
231.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 12,249,1977

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-Chloro-5-nitropyrimidin-4-amine
  • 2-amino-6-methylpyridine-3-thiol

DownStream

Related Compounds

  • N-Cyclohexyl-5,6,7,8-tetrahydroquinazoline-4-carboxamide
  • 5-Chloro-2-{[1-(oxolane-2-carbonyl)piperidin-4-yl]oxy}pyrimidine
  • N-(1-Thieno[3,2-d]pyrimidin-4-ylazetidin-3-yl)cyclobutanecarboxamide
  • N-[(1r,4r)-4-methylcyclohexyl]-5,6,7,8-tetrahydroquinazoline-4-carboxamide
  • N-[6-(1,3-dioxolan-2-yl)-2-pyridinyl]-N-methylcarbamic acid phenyl ester
  • Piperidine-3,5-diol hydrochloride
  • Ethyl 7-fluoro-1,4-dihydro-1-(4-methoxybutyl)-4-oxo-3-quinolinecarboxylate
  • (3-Bromo-2-chloro-5-fluorophenyl)boronic acid
  • 4,4',4",4'",4"",4""'-(Triphenylene-2,3,6,7,10,11-hexayl)hexabenzonitrile
  • 4,6-Dichloro-2,3-dihydro-7-methoxy-1H-indole
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