8-Methyl-10H-pyrido(3,2-b)pyrimido(4,5-e)(1,4)thiazin-4-amine

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Names

[ CAS No. ]:
55740-63-1

[ Name ]:
8-Methyl-10H-pyrido(3,2-b)pyrimido(4,5-e)(1,4)thiazin-4-amine

[Synonym ]:
4-Amino-8-methyl-1,3,9-triazaphenotriazin
4-Amino-8-methyl-1,3,9-triazaphenothiazin

Chemical & Physical Properties

[ Density]:
1.447g/cm3

[ Boiling Point ]:
486.4ºC at 760 mmHg

[ Molecular Formula ]:
C10H9N5S

[ Molecular Weight ]:
231.27700

[ Flash Point ]:
248ºC

[ Exact Mass ]:
231.05800

[ PSA ]:
105.25000

[ LogP ]:
1.40910

[ Index of Refraction ]:
1.733

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1173100
CHEMICAL NAME :
10H-Pyrido(3,2-b)pyrimido(4,5-e)(1,4)thiazin-4-amine, 8-methyl-
CAS REGISTRY NUMBER :
55740-63-1
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H9-N5-S
MOLECULAR WEIGHT :
231.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 12,249,1977

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-Chloro-5-nitropyrimidin-4-amine
  • 2-amino-6-methylpyridine-3-thiol

DownStream

Related Compounds

  • 3-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]acetamido}-2-hydroxypropanoic acid
  • (3S,6R,10R,13E,16S)-10-[(3,5-dichloro-4-hydroxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1R)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
  • 5-{[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methyloxolan-3-yl]formamido}pentanoic acid
  • 3-Ethoxy-1-(5-methylthiophen-3-yl)prop-2-en-1-one
  • 4-Methyl-1-(5-methylthiophen-3-yl)pentane-1,3-dione
  • 2-amino-3-(4,5-dibromo-2-methyl-1H-imidazol-1-yl)butanamide
  • 2-(Diethylsulfamoyl)ethane-1-sulfonyl chloride
  • N-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}bicyclo[1.1.1]pentane-1-carboxamide
  • tert-butyl N-[3-(2-phenylethyl)bicyclo[1.1.1]pentan-1-yl]carbamate
  • [3-(1,1-Difluoroethyl)bicyclo[1.1.1]pentan-1-yl]hydrazine dihydrochloride
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