Nicardipine

Suppliers

Names

[ CAS No. ]:
55985-32-5

[ Name ]:
Nicardipine

[Synonym ]:
Cardene IV
Cardene SR
Nicardipino
MFCD00216027
nicardipine
Nicardipine LA
Nicardipinum
EINECS 259-932-3

Chemical & Physical Properties

[ Density]:
1.23 g/cm3

[ Boiling Point ]:
603.4ºC at 760 mmHg

[ Melting Point ]:
136-138ºC

[ Molecular Formula ]:
C26H29N3O6

[ Molecular Weight ]:
479.52500

[ Flash Point ]:
318.7ºC

[ Exact Mass ]:
479.20600

[ PSA ]:
113.69000

[ LogP ]:
4.52980

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US7972050
CHEMICAL NAME :
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(benzylmethylamino)ethyl methyl ester
CAS REGISTRY NUMBER :
55985-32-5
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C26-H29-N3-O6
MOLECULAR WEIGHT :
479.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,915,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4710505
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
305 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4824855
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4672068

Synthetic Route

Precursor & DownStream

Precursor

  • 3-nitrooxypropyl 3-oxobutanoate
  • 3-nitroxypropyl 2-(3-cyanobenzylidene)acetoacetate
  • 2-hydroxyethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • N-Methylbenzylamine

DownStream

  • Nitrendipine
  • 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • Nisoldipine
  • UNII:5DU0E310OI

Related Compounds

  • nicardipine
  • (-)nicardipine
  • Nicardipine HCl
  • Nicardipine HCl
  • (R)-Nicardipine
  • (S)-Nicardipine
  • 2-(Cyclopropylmethyl)-4-iodophenol
  • N-((1-methyl-5-(thiophen-2-yl)-1H-pyrazol-3-yl)methyl)-2-(naphthalen-1-yl)acetamide
  • 6,6-dimethyl-5,7-dihydropyrazolo[5,1-b][1,3]oxazine-3-carbonyl chloride
  • Methyl 5-[(cyanomethyl)(ethyl)carbamoyl]furan-3-carboxylate
  • 6-methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carbonyl chloride
  • 2-[2-Fluoro-4-(trifluoromethyl)phenyl]pyrrolidine
  • 6-Methyl-N-(2-methylcyclohexyl)pyridin-3-amine
  • 6-methyl-N-(thiolan-3-yl)pyridin-3-amine
  • 2-(azetidin-3-yl)-6-methoxy-1H-benzimidazole
  • 2-Oxoindoline-5-carbonyl chloride
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.