Nicardipine

Suppliers

Names

[ CAS No. ]:
55985-32-5

[ Name ]:
Nicardipine

[Synonym ]:
Cardene IV
Cardene SR
Nicardipino
MFCD00216027
nicardipine
Nicardipine LA
Nicardipinum
EINECS 259-932-3

Chemical & Physical Properties

[ Density]:
1.23 g/cm3

[ Boiling Point ]:
603.4ºC at 760 mmHg

[ Melting Point ]:
136-138ºC

[ Molecular Formula ]:
C₂₆H₂₉N₃O₆

[ Molecular Weight ]:
479.52500

[ Flash Point ]:
318.7ºC

[ Exact Mass ]:
479.20600

[ PSA ]:
113.69000

[ LogP ]:
4.52980

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7972050

CHEMICAL NAME :: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(benzylmethylamino)ethyl methyl ester

CAS REGISTRY NUMBER :: 55985-32-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C26-H29-N3-O6

MOLECULAR WEIGHT :: 479.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,915,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4710505

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 305 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4824855

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4672068

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-nitrooxypropyl 3-oxobutanoate
3-nitroxypropyl 2-(3-cyanobenzylidene)acetoacetate
2-hydroxyethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
N-Methylbenzylamine

DownStream

Nitrendipine
2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Nisoldipine
UNII:5DU0E310OI

Related Compounds

nicardipine
(-)nicardipine
Nicardipine HCl
Nicardipine HCl
(R)-Nicardipine
(S)-Nicardipine
4-(2-(4-(2-chlorophenyl)piperazin-1-yl)-2-oxoethyl)-7-methyl-2H-chromen-2-one
N-(4,7-dimethylbenzo[d]thiazol-2-yl)-N-((tetrahydrofuran-2-yl)methyl)-1H-indole-3-carboxamide
N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-2-(2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)-N-[(oxolan-2-yl)methyl]acetamide
N-(4,7-dimethoxybenzo[d]thiazol-2-yl)-3-methoxy-1-methyl-N-((tetrahydrofuran-2-yl)methyl)-1H-pyrazole-4-carboxamide
3-Methoxy-3-phenylazetidine
Methyl 2-{3-[4,6-dimethyl-2-(methylsulfanyl)pyrimidin-5-yl]propanamido}-3-phenylpropanoate
n-(1-(Cyclopentylamino)-1-oxopropan-2-yl)furan-2-carboxamide
3-Amino-3-(pyridin-4-YL)propanamide
(E)-N-[1-(2-bromophenyl)ethyl]-2-phenylethenesulfonamide
(E)-1-(1H-pyrrol-2-yl)-3-(quinoxalin-6-yl)prop-2-en-1-one

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