Chlorphenoxamine Hydrochloride

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Names

[ CAS No. ]:
562-09-4

[ Name ]:
Chlorphenoxamine Hydrochloride

[Synonym ]:
Systral
EINECS 209-227-1
Chlorphenoxamine HCl
{2-[1-(4-chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-dimethyl-amine,hydrochloride
chlophenoxamine hydrochloride
Phenoxene
chlorophenoxamine hydrochloride
Contristamine,hydrochloride
2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethylethanamine hydrochloride
Chlorphenoxamine hydrochloride
Substanz NR. 1766 [German]
{2-[1-(4-Chlor-phenyl)-1-phenyl-aethoxy]-aethyl}-dimethyl-amin,Hydrochlorid
Phenoxene hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
383.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₃Cl₂NO

[ Molecular Weight ]:
340.28700

[ Flash Point ]:
185.9ºC

[ Exact Mass ]:
339.11600

[ PSA ]:
12.47000

[ LogP ]:
4.98370

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KR2975000

CHEMICAL NAME :: Ethylamine, 2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N -dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 562-09-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H22-Cl-N-O.Cl-H

MOLECULAR WEIGHT :: 340.32

WISWESSER LINE NOTATION :: GR DX1&R&O2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,31,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,262,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 161 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,83,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 159 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,262,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,262,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 30800 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,638,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,189,1954

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

Tyrocidine, hydrochloride
Triprolidine hydrochloride
Minoxidil hydrochloride
Elacridar hydrochloride
dodecylamine hydrochloride
Azetidine, hydrochloride, homopolymer (9CI)
N-[4-({4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1H-imidazol-1-yl}methyl)phenyl]-3,5-dimethoxybenzamide
5-Chloro-2-(piperidin-1-ylcarbonyl)pyridine
N-[2-(3,4-dimethoxyphenyl)ethyl]-3-[(4-oxoquinazolin-3(4H)-yl)methyl]-1,2,4-oxadiazole-5-carboxamide
4-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinolin-2-ylamine
4-[4-(4-Amino-5-methyl-pyrimidin-2-ylamino)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester
2,2-Dimethyl-1-[2-(pyridin-3-yl)pyrrolidin-1-yl]propan-1-one
5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinolin-1-ylamine
2-Chloro-N-(3-methoxyphenyl)-N-propylacetamide
4-Phenyl-piperidine-4-carboxylic acid benzyl-methyl-amide
n-[1-(2-Amino-ethyl)-piperidin-4-yl]-n-ethyl-4-methoxy-benzenesulfonamide

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