3,6-Dimethyl-2,5-piperazinedione

Names

[ Name ]:
3,6-Dimethyl-2,5-piperazinedione

[Synonym ]:
3,6-Dimethyl-2,5-piperazinedione
3,6-dimethylpiperazine-2,5-dione
EINECS 227-058-1
2,5-Piperazinedione, 3,6-dimethyl-
MFCD00023153
3,6-Dimethyl Piperazine-2,5-Dione

Chemical & Physical Properties

[ Density]:
1.081

[ Boiling Point ]:
453.0±38.0 °C at 760 mmHg

[ Melting Point ]:
283-285ºC(lit.)

[ Molecular Formula ]:
C₆H₁₀N₂O₂

[ Molecular Weight ]:
142.156

[ Flash Point ]:
227.9±26.9 °C

[ Exact Mass ]:
142.074234

[ PSA ]:
58.20000

[ LogP ]:
-1.58

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.442

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6380150

CHEMICAL NAME :: 2,5-Piperazinedione, 3,6-dimethyl-

CAS REGISTRY NUMBER :: 5625-46-7

BEILSTEIN REFERENCE NO. :: 0082120

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H10-N2-O2

MOLECULAR WEIGHT :: 142.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 4,167,1969

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ RTECS ]:
TL6380150

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

H-D-Ala-Ala-OH
DL-Alanine
Z-L-Ala-D-Ala-OMe
L-alanine
D-alanine
2-amino-propionic acid ethyl ester
ethyl (2S)-2-aminopropanoate
Ethanol
2,5-Piperazinedione,3-methyl-6-methylene-,(S)-(9CI)
methyl L-alaninate

DownStream

Ammonia
acetic acid
DL-Alanine
(2R,5S)-2,5-Dimethylpiperazine
3-Chloro-2,5-dimethylpyrazine
2,5-dichloro-3,6-dimethylpyrazine
2,5-dibromo-3,6-dimethylpyrazine
methane
ethane
2,5-Piperazinedione,3,3,6-trimethyl-(9CI)

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Bond dissociation of the dipeptide dialanine and its derivative alanine anhydride induced by low energy electrons.

J. Chem. Phys. 134(5) , 054305, (2011)

Dissociative electron attachment to dialanine and alanine anhydride has been studied in the gas phase utilizing a double focusing two sector field mass spectrometer. We show that low-energy electrons ...

The synthesis of peptides by transamination. Herbst RM and Shemin D.

J. Biol. Chem. 147(3) , 541-7, (1943)

Synthesis of Aliphatic Poly (ester-amide) s by Ring-Opening Polymerization of L-Lactide and Amino Acid Anhydrides. Noomhorma C and Tokiwab Y.

ScienceAsia 34(1) , 43-47, (2008)

(3R,6R)-3,6-Dimethyl-2,5-piperazinedione
(3S,6S)-3,6-Dimethyl-2,5-piperazinedione
(3S,6R)-1-Allyl-3,6-dimethyl-2,5-piperazinedione
(3R,6S)-3-Hydroxy-3,6-dimethyl-2,5-piperazinedione
3,6-dimethyl-2,5-dihydropyran-6-carbaldehyde
3,6-dimethyl-2,5,6,7-tetrahydrocyclopenta[c]pyridin-1-one
2-(6-Chloropyridin-2-yl)propanal
7-Azadispiro[3.0.5^{5}.1^{4}]undecane-6,9-dione
3-Pyrrolidinecarboxylic acid, 4-(1-methyl-1H-pyrrol-3-yl)-, ethyl ester
Methylamino-peg2-acid hydrochloride salt
3-(oxiran-2-yl)-3,4-dihydro-2H-1-benzopyran
6-Bromo-7-chloroimidazo[1,2-a]pyridine-3-carboxylic acid
tert-butyl N-(2-azidoethyl)-N-[2-[[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]amino]-2-oxo-ethyl]carbamate
1-(Hydroxymethyl)-3-(trifluoromethyl)cyclohexane-1-carboxylic acid
tert-butyl N-[2-(2-azidoethoxy)ethyl]-N-[2-[[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]amino]-2-oxo-ethyl]carbamate
3,4-Dihydro-7-hydroxy-8-(3-methylbutyl)-4-phenyl-2H-1-benzopyran-2-one

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