Benzetimide hydrochloride

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Names

[ CAS No. ]:
5633-14-7

[ Name ]:
Benzetimide hydrochloride

[Synonym ]:
Dioxatrine
1'-Benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione hydrochloride (1:1)
Spasmentral
R 4929
Benzetimide HCl
EINECS 227-072-8
[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, hydrochloride (1:1)
McN-JR4929
BENZETIMIDE HYDROCHLORIDE
Benzetimide (hydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
543.9ºC at 760 mmHg

[ Molecular Formula ]:
C23H27ClN2O2

[ Molecular Weight ]:
398.926

[ Flash Point ]:
282.7ºC

[ Exact Mass ]:
398.176117

[ PSA ]:
52.90000

[ LogP ]:
4.28900

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA4030000
CHEMICAL NAME :
Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, hydrochloride
CAS REGISTRY NUMBER :
5633-14-7
LAST UPDATED :
199707
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C23-H26-N2-O2.Cl-H
MOLECULAR WEIGHT :
398.97
WISWESSER LINE NOTATION :
T6VMVTJ DR& D- DT6NTJ A1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37600 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,283,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1365,1971

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Related Compounds

  • Triprolidine hydrochloride
  • Elacridar hydrochloride
  • Minoxidil hydrochloride
  • Tyrocidine, hydrochloride
  • dodecylamine hydrochloride
  • Ebaresdax hydrochloride
  • 2-[4-(Hydroxymethyl)phenyl]-2-{[(prop-2-en-1-yloxy)carbonyl]amino}acetic acid
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 3-(4-methoxybenzenesulfonyl)-2-methylpropanoate
  • 3-(2-Hydroxyphenyl)-2-{[(prop-2-en-1-yloxy)carbonyl]amino}propanoic acid
  • 3-(Methoxymethyl)-5-{[(prop-2-en-1-yloxy)carbonyl]amino}benzoic acid
  • 3-(4-{[(Prop-2-en-1-yloxy)carbonyl]amino}phenoxy)propanoic acid
  • 2-(3-Methoxyphenyl)-2-{[(prop-2-en-1-yloxy)carbonyl]amino}acetic acid
  • 3-(2-{[(Prop-2-en-1-yloxy)carbonyl]amino}phenoxy)propanoic acid
  • 2-[2-({[(Prop-2-en-1-yloxy)carbonyl]amino}methyl)phenoxy]acetic acid
  • (2R,3S)-2-hydroxy-3-phenyl-3-{[(prop-2-en-1-yloxy)carbonyl]amino}propanoic acid
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 6-[methyl(2-methylpropyl)carbamoyl]pyridine-2-carboxylate
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