Nosiheptide

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Names

[ Name ]:
Nosiheptide

[Synonym ]:
2-[(1S,7S,14S,16S)-10-(Z)-ethylidene-35,16-dihydroxy-7-((R)-1-hydroxy-ethyl)-203-methyl-5,8,12,17,21,25-hexaoxo-201H-18-oxa-22-thia-6,9,13,24-tetraaza-20(4,2)-indola-3(2,3)-pyridina-2,4,11,26(2,4)-tetrakis-thiazola-bicyclo[12.9.3]hexacosaphan-36-yl]-thiazole-4-carboxylic acid 1-carbamoyl-vinylamide
Multhiomycin
Nosiheptide
priMofax
N-[1-(Aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-4-thiazolecarboxamide
N-(3-Amino-3-oxoprop-1-en-2-yl)-2-[(21Z)-21-ethylidene-9,30-dihydroxy-18-(1-hydroxyethyl)-40-methyl-16,19,26,31,42,46-hexaoxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyclo[26.16.6.1.1.1.1.1.0.0]pentapentaconta-2(55),4,6,8,10,12(54),14,22(53),24,34,36,38,40,47,50-pentadecaen-8-yl]-1,3-thiazole-4-carboxamide
N-(3-amino-3-oxoprop-1-en-2-yl)-2-[(21Z)-21-ethylidene-9,30-dihydroxy-18-(1-hydroxyethyl)-40-methyl-16,19,26,31,42,46-hexaoxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyclo[26.16.6.1.1.1.1.1.0.0]pentapentaconta-2(55),4,6,8,10,12(54),14,22(53),24,34,36,38,40,47,50-pentadecaen-8-yl]-1,3-thiazole-4-carboxamide (non-preferred name)
N-(3-Amino-3-oxo-1-propen-2-yl)-2-[(21Z)-21-ethylidene-9,30-dihydroxy-18-(1-hydroxyethyl)-40-methyl-16,19,26,31,42,46-hexaoxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyc ;lo[26.16.6.1.1.1.1.1.0.0]pentapentaconta-2(55),4,6,8,10,12(54),14,22(53),24,34,36,38,40,47,50-pentadecaen-8-yl]-1,3-thiazole-4-carboxamide

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
310-320° (dec)

[ Molecular Formula ]:
C₅₁H₄₃N₁₃O₁₂S₆

[ Molecular Weight ]:
1222.357

[ Exact Mass ]:
1221.147827

[ PSA ]:
552.28000

[ LogP ]:
0.72

[ Index of Refraction ]:
1.699

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD2685000

CHEMICAL NAME :: Nosiheptide

CAS REGISTRY NUMBER :: 56377-79-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C51-H43-N13-O12-S6

MOLECULAR WEIGHT :: 1222.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 23,231,1970

Related Compounds

3-[(6-Nitroquinazolin-4-yl)amino]propane-1,2-diol
N-methyl-1-(pyridin-2-yl)cyclopropan-1-amine
[1-(Cyclopentylmethyl)azetidin-3-yl]methanol
2-[3-(Hydroxymethyl)azetidin-1-yl]acetic acid
2-Cyclopropyl-2-hydroxyacetaldehyde
1-Amino-4-methylheptan-2-ol
1-Amino-3-(oxan-4-yl)propan-2-ol
1-(Methylamino)-4-(thiophen-3-yl)butan-2-ol
Propanoic acid, 3-[[(3-ethyl-4-methyl-1-piperazinyl)carbonyl]amino]-2-hydroxy-2-methyl-
1-[4-(Aminomethyl)piperidin-1-yl]-2-methoxyethan-1-one

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