Metoprolol Acid

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Names

[ Name ]:
Metoprolol Acid

[Synonym ]:
2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetic acid
Metoprolol acid
SL 77-010
H 117/04
Atenolol acid
Atenolol Impurity 7

Chemical & Physical Properties

[ Density]:
1.159g/cm3

[ Boiling Point ]:
477.1ºC at 760mmHg

[ Melting Point ]:
174-176ºC

[ Molecular Formula ]:
C₁₄H₂₁NO₄

[ Molecular Weight ]:
267.32100

[ Flash Point ]:
242.3ºC

[ Exact Mass ]:
267.14700

[ PSA ]:
78.79000

[ LogP ]:
1.44230

[ Index of Refraction ]:
1.539

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1634360

CHEMICAL NAME :: Benzeneacetic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-

CAS REGISTRY NUMBER :: 56392-14-4

LAST UPDATED :: 199110

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H21-N-O4

MOLECULAR WEIGHT :: 267.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,186,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
CY1634360

Articles

The impact of different proportions of a treated effluent on the biotransformation of selected micro-contaminants in river water microcosms.

Int. J. Environ. Res. Public Health 11(10) , 10390-405, (2014)

Attenuation of micro-contaminants is a very complex field in environmental science and evidence suggests that biodegradation rates of micro-contaminants in the aqueous environment depend on the water ...

Pregnancy-induced increase in metoprolol metabolism.

Clin. Pharmacol. Ther. 37(6) , 688-92, (1985)

Five women who developed hypertension during pregnancy received metoprolol, 10 mg iv; 3 days later they received metoprolol, 100 mg by mouth. Blood and urine samples were collected after each dose. Th...

Determination of two metoprolol metabolites in human urine by high-performance liquid chromatography.

J. Chromatogr. A. 309(1) , 198-202, (1984)

Metoprolol Acid-d5
Metoprolol Acid Ethyl Ester
Metoprolol Acid-d5 Ethyl Ester
Metoprolol (succinate)
Octanethioic acid S-propyl ester
Hexanethioic acid S-decyl ester
(2R)-2-{[(1RS,2SR)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopentyl]formamido}-3-hydroxypropanoic acid
(3R)-3-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]hexanoic acid
4-ethyl-1-methyl-3-(2-methylpentan-3-yl)-1H-pyrazol-5-amine
5-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]-1-methyl-1H-pyrazole-3-carboxylic acid
1-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoyl]azetidine-3-carboxylic acid
1-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]cyclopropane-1-carboxylic acid
2-ethyl-1-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoyl]pyrrolidine-2-carboxylic acid
4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hex-4-ynamido]-2,2-dimethylbutanoic acid
3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(propan-2-yl)hex-4-ynamido]propanoic acid
1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hex-4-ynoyl]-3,4-dimethylpyrrolidine-3-carboxylic acid

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