Benzenesulfonamide,3-amino-N-(5-chloro-2-pyrimidinyl)-

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Names

[ CAS No. ]:
565-36-6

[ Name ]:
Benzenesulfonamide,3-amino-N-(5-chloro-2-pyrimidinyl)-

[Synonym ]:
Metachloridine
WR-6010
3-amino-N-5-chloropyrimidin-2-ylbenzenesulphonamide

Chemical & Physical Properties

[ Density]:
1.588g/cm3

[ Boiling Point ]:
554.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₉ClN₄O₂S

[ Molecular Weight ]:
284.72200

[ Flash Point ]:
289.4ºC

[ Exact Mass ]:
284.01300

[ PSA ]:
106.35000

[ LogP ]:
3.24800

[ Index of Refraction ]:
1.683

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OY2210000

CHEMICAL NAME :: Metanilamide, N'-(5-chloro-2-pyrimidyl)-

CAS REGISTRY NUMBER :: 565-36-6

BEILSTEIN REFERENCE NO. :: 0261399

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H9-Cl-N4-O2-S

MOLECULAR WEIGHT :: 284.74

WISWESSER LINE NOTATION :: T6N CNJ BMSWR CZ& EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 13,289,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,469,1971

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,469,1971

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1083 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 13,289,1968

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-nitro-benzenesulfonic acid-(5-chloro-pyrimidin-2-ylamide)
3-nitrobenzenesulfonyl bromide
3-Nitrophenylsulfonyl chloride

DownStream

Related Compounds

4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine