Pregnane-11,20-dione,3-hydroxy-, (3a,5b)-

Suppliers

Names

[ CAS No. ]:
565-99-1

[ Name ]:
Pregnane-11,20-dione,3-hydroxy-, (3a,5b)-

[Synonym ]:
11-Oxopregnanolone
3alpha-Hydroxy-11,20-pregnadien
3alpha-Hydroxy-5beta-pregnane-11,20-dione
Renanolone
11-Ketopregnanolone

Chemical & Physical Properties

[ Density]:
1.212g/cm3

[ Boiling Point ]:
504ºC at 760mmHg

[ Molecular Formula ]:
C21H32O3

[ Molecular Weight ]:
332.47700

[ Flash Point ]:
272.7ºC

[ Exact Mass ]:
332.23500

[ PSA ]:
54.37000

[ LogP ]:
3.77420

[ Index of Refraction ]:
1.562

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4157900
CHEMICAL NAME :
5-beta-Pregnane-11,20-dione, 3-alpha-hydroxy-
CAS REGISTRY NUMBER :
565-99-1
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H32-O3
MOLECULAR WEIGHT :
332.53
WISWESSER LINE NOTATION :
L E5 B666 CVTJ A1 E1 FV1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

Precursor & DownStream

Precursor

DownStream

  • 5.alpha.-Pregnane-11,20-dione, 21-bromo-3.beta., 17.alpha.-dihydroxy-

Related Compounds

  • Pregnane-11,20-dione,3-(acetyloxy)-, (3a,5b)- (9CI)
  • Pregnane-11,20-dione,3,21-dihydroxy-, (3a,5b)-
  • Pregnane-11,20-dione,3,17-dihydroxy-, (3a,5b)- (9CI)
  • Pregnane-11,20-dione,3-hydroxy-, (3b,5a)-
  • Pregnane-11,20-dione,21-(acetyloxy)-3,17-dihydroxy-, (3a,5b)- (9CI)
  • Pregnane-11,20-dione,3-(acetyloxy)-16-bromo-17-hydroxy-, (3b,5a,16b)- (9CI)
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazole-5-carboxamide
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide